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BID and GBP2
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
BID
GBP2
Description
BH3 interacting domain death agonist
guanylate binding protein 2
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Membrane
Mitochondrial Membrane
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Molecular Function
Death Receptor Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process
Nucleotide Binding
GTPase Activity
Endopeptidase Inhibitor Activity
Protein Binding
GTP Binding
Hydrolase Activity
Identical Protein Binding
Protein Homodimerization Activity
Molecular Function Inhibitor Activity
Biological Process
Release Of Cytochrome C From Mitochondria
Protein Targeting To Mitochondrion
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Apoptotic Mitochondrial Changes
Positive Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Protein-containing Complex Assembly
Cellular Response To Stress
Intracellular Signal Transduction
Regulation Of T Cell Proliferation
Signal Transduction In Response To DNA Damage
Mitochondrial ATP Synthesis Coupled Electron Transport
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of Epithelial Cell Proliferation
Neuron Apoptotic Process
Protein-containing Complex Assembly
Establishment Of Protein Localization To Membrane
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway
Hepatocyte Apoptotic Process
Mitochondrial Outer Membrane Permeabilization
Supramolecular Fiber Organization
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Intracellular Signal Transduction
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Fibroblast Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Activation Of Innate Immune Response
Immune System Process
Immune Response
Protein Localization To Nucleus
Defense Response To Bacterium
Defense Response To Protozoan
Innate Immune Response
Symbiont Entry Into Host Cell
Defense Response To Gram-positive Bacterium
Protein Maturation
Defense Response To Virus
Cytolysis In Another Organism
Cellular Response To Lipopolysaccharide
Cellular Response To Type II Interferon
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of AIM2 Inflammasome Complex Assembly
Pathways
Activation of BAD and translocation to mitochondria
Activation and oligomerization of BAK protein
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation, translocation and oligomerization of BAX
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Activation, myristolyation of BID and translocation to mitochondria
Interferon gamma signaling
Interferon alpha/beta signaling
CASP4 inflammasome assembly
Microbial factors inhibit CASP4 activity
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Diisocyanate-induced asthma (
25918132
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Serum metabolite levels (
33031748
)
Interacting Genes
36 interacting genes:
AHCYL1
BAK1
BAX
BCL2
BCL2A1
BCL2L1
BCL2L2
CAPN1
CAPN2
CASP1
CASP10
CASP2
CASP3
CASP8
CRMP1
CRNKL1
CSNK1A1
CSNK1E
CSNK2A1
CSNK2A2
CSNK2B
DDIT4L
ERG28
FBN3
GAPDH
GBP2
GZMB
MCL1
PLEKHM1
RBM48
REL
SETDB1
TLE1
TUBB2B
YWHAB
ZHX1
22 interacting genes:
ANXA7
BID
BNIP3L
BTBD2
CSNK2B
FBXO7
FXR1
GADD45A
GSK3B
HSPE1
KLHL20
LSM2
MAGI1
MAPK8IP2
PAFAH1B3
PPP1R8
RPS6KA1
SAT1
SEPHS1
SERPINB9
STK3
TFG
Entrez ID
637
2634
HPRD ID
03590
02682
Ensembl ID
ENSG00000015475
ENSG00000162645
Uniprot IDs
A8ASI8
B2ZP79
B3KT21
P55957
P32456
Q8TCE5
PDB IDs
1ZY3
2BID
2KBW
2M5B
2M5I
4BD2
4QVE
4ZEQ
4ZIG
4ZII
5AJJ
5C3F
7M5A
7M5B
7P33
7QTW
8SM5
6VKJ
7E58
7M1S
Enriched GO Terms of Interacting Partners
?
Bcl-2 Family Protein Complex
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Release Of Cytochrome C From Mitochondria
Apoptotic Process
Cell Death
Programmed Cell Death
Channel Activity
Extrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Execution Phase Of Apoptosis
Apoptotic Mitochondrial Changes
Intrinsic Apoptotic Signaling Pathway
BH3 Domain Binding
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Protein Kinase CK2 Complex
Mitochondrial Outer Membrane
Cysteine-type Peptidase Activity
Regulation Of Apoptotic Process
Protein Maturation
Regulation Of Programmed Cell Death
Identical Protein Binding
Leukocyte Apoptotic Process
DNA Damage Response
Regulation Of Neuron Apoptotic Process
Mitochondrial Fusion
Negative Regulation Of Anoikis
Regulation Of Autophagy
Signal Transduction
Programmed Cell Death Involved In Cell Development
Response To Cytokine
Response To Peptide
Negative Regulation Of Programmed Cell Death
Regulation Of Anoikis
Cysteine-type Endopeptidase Activity
Peptidase Activity
B Cell Homeostasis
Cytosol
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Pyroptotic Inflammatory Response
Mitochondrion Organization
Regulation Of Proteolysis
Negative Regulation Of Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Response To Stress
B Cell Apoptotic Process
Pyroptotic Inflammatory Response
Cytoplasm
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Membrane Permeability
Positive Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Mitochondrial Membrane Permeability
Mitochondrial Outer Membrane Permeabilization
Positive Regulation Of Intracellular Signal Transduction
Protein Heterodimerization Activity
Regulation Of Membrane Permeability
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Protein-containing Complex Assembly
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Hepatocyte Apoptotic Process
Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Negative Regulation Of Apoptotic Signaling Pathway
Protein-containing Complex Organization
Mitochondrial Membrane Organization
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Catabolic Process
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Protein Targeting To Mitochondrion
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Regulation Of Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Negative Regulation Of Proteolysis
Protein Phosphorylation
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Catalytic Activity
Regulation Of JNK Cascade
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Presynaptic Modulation Of Chemical Synaptic Transmission
Regulation Of Microtubule Anchoring At Centrosome
Cytoplasmic Translational Initiation
Ribonuclease E Activity
Spermidine Binding
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Type II Interferon Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Autophagy
Phosphorylation
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