Wiki-Pi
About
Search
People
Updates
Search
BID and BAK1
Number of citations of the paper that reports this interaction (PubMedID
10950869
)
50
Data Source:
HPRD
(in vivo, in vitro)
BID
BAK1
Description
BH3 interacting domain death agonist
BCL2 antagonist/killer 1
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Membrane
Mitochondrial Membrane
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Cytosol
Membrane
Mitochondrial Membrane
Pore Complex
Bcl-2 Family Protein Complex
BAK Complex
Molecular Function
Death Receptor Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process
Protein Binding
Channel Activity
Porin Activity
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Transmembrane Transporter Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Protein-folding Chaperone Binding
BH Domain Binding
Biological Process
Release Of Cytochrome C From Mitochondria
Protein Targeting To Mitochondrion
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Apoptotic Mitochondrial Changes
Positive Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Protein-containing Complex Assembly
Cellular Response To Stress
Intracellular Signal Transduction
Regulation Of T Cell Proliferation
Signal Transduction In Response To DNA Damage
Mitochondrial ATP Synthesis Coupled Electron Transport
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of Epithelial Cell Proliferation
Neuron Apoptotic Process
Protein-containing Complex Assembly
Establishment Of Protein Localization To Membrane
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway
Hepatocyte Apoptotic Process
Mitochondrial Outer Membrane Permeabilization
Supramolecular Fiber Organization
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Intracellular Signal Transduction
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Fibroblast Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Leukocyte Homeostasis
B Cell Homeostasis
B Cell Apoptotic Process
Release Of Cytochrome C From Mitochondria
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
Apoptotic Process
Mitochondrial Fusion
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Response To Fungus
Response To Mycotoxin
Response To UV-C
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Gene Expression
Endocrine Pancreas Development
Animal Organ Regeneration
Positive Regulation Of Protein-containing Complex Assembly
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Monoatomic Ion Transmembrane Transport
Cellular Response To Unfolded Protein
Cellular Response To UV
Limb Morphogenesis
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Fibroblast Apoptotic Process
Response To Ethanol
Positive Regulation Of Proteolysis
Regulation Of Mitochondrial Membrane Permeability
Post-embryonic Camera-type Eye Morphogenesis
Homeostasis Of Number Of Cells
Epithelial Cell Proliferation
Regulation Of Transport
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Mitochondrial Membrane Potential
Vagina Development
Calcium Ion Transport Into Cytosol
Regulation Of Biological Quality
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Blood Vessel Morphogenesis
Regulation Of Intracellular Signal Transduction
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of Apoptotic Signaling Pathway
Pathways
Activation of BAD and translocation to mitochondria
Activation and oligomerization of BAK protein
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation, translocation and oligomerization of BAX
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Activation, myristolyation of BID and translocation to mitochondria
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria
Pyroptosis
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Diisocyanate-induced asthma (
25918132
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Autism spectrum disorder or schizophrenia (
28540026
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Body mass index (
26426971
)
Chronic lymphocytic leukemia (
24292274
28165464
23770605
22700719
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
27841878
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Hematological parameters (
19820697
)
Lung cancer (
28604730
)
Multiple sclerosis and systolic blood pressure (pleiotropy) (
26920376
)
Neutrophil percentage of granulocytes (
27863252
)
Obesity-related traits (
23251661
)
Platelet count (
29066854
27863252
29403010
32888494
33545615
28031487
20139978
26805783
25705162
24026423
22139419
22423221
23263863
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Schizophrenia (
30285260
)
Spleen volume (
34128465
)
Sum eosinophil basophil counts (
27863252
)
Testicular germ cell tumor (
23666239
23666240
28604732
28604728
19483681
)
Interacting Genes
36 interacting genes:
AHCYL1
BAK1
BAX
BCL2
BCL2A1
BCL2L1
BCL2L2
CAPN1
CAPN2
CASP1
CASP10
CASP2
CASP3
CASP8
CRMP1
CRNKL1
CSNK1A1
CSNK1E
CSNK2A1
CSNK2A2
CSNK2B
DDIT4L
ERG28
FBN3
GAPDH
GBP2
GZMB
MCL1
PLEKHM1
RBM48
REL
SETDB1
TLE1
TUBB2B
YWHAB
ZHX1
20 interacting genes:
ARHGDIA
BAX
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BID
DBN1
ERN1
HERC1
HSD17B4
HSPD1
MCL1
MFN1
NFKBIB
TP53
UBE3A
VDAC1
VDAC2
Entrez ID
637
578
HPRD ID
03590
02744
Ensembl ID
ENSG00000015475
ENSG00000030110
Uniprot IDs
A8ASI8
B2ZP79
B3KT21
P55957
A0A0S2Z391
Q16611
PDB IDs
1ZY3
2BID
2KBW
2M5B
2M5I
4BD2
4QVE
4ZEQ
4ZIG
4ZII
5AJJ
5C3F
7M5A
7M5B
7P33
7QTW
8SM5
1BXL
2IMS
2IMT
2JBY
2JCN
2LP8
2M5B
2XPX
2YV6
3I1H
3QBR
4D2L
4U2U
4U2V
4UF1
5AJK
5FMI
5FMK
5VWV
5VWW
5VWX
5VWY
5VWZ
5VX0
5VX1
6ODH
6UXM
6UXN
6UXO
6UXP
6UXQ
6UXR
7K02
7LK4
7M5A
7M5B
7OFM
7OFO
8CZF
8CZG
8CZH
8GSV
8IGC
8IVB
8SRX
8SRY
8UKY
8Y1Y
8Y1Z
Enriched GO Terms of Interacting Partners
?
Bcl-2 Family Protein Complex
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Release Of Cytochrome C From Mitochondria
Apoptotic Process
Cell Death
Programmed Cell Death
Channel Activity
Extrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Execution Phase Of Apoptosis
Apoptotic Mitochondrial Changes
Intrinsic Apoptotic Signaling Pathway
BH3 Domain Binding
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Protein Kinase CK2 Complex
Mitochondrial Outer Membrane
Cysteine-type Peptidase Activity
Regulation Of Apoptotic Process
Protein Maturation
Regulation Of Programmed Cell Death
Identical Protein Binding
Leukocyte Apoptotic Process
DNA Damage Response
Regulation Of Neuron Apoptotic Process
Mitochondrial Fusion
Negative Regulation Of Anoikis
Regulation Of Autophagy
Signal Transduction
Programmed Cell Death Involved In Cell Development
Response To Cytokine
Response To Peptide
Negative Regulation Of Programmed Cell Death
Regulation Of Anoikis
Cysteine-type Endopeptidase Activity
Peptidase Activity
B Cell Homeostasis
Cytosol
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Pyroptotic Inflammatory Response
Mitochondrion Organization
Regulation Of Proteolysis
Negative Regulation Of Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Response To Stress
B Cell Apoptotic Process
Pyroptotic Inflammatory Response
Apoptotic Mitochondrial Changes
Release Of Cytochrome C From Mitochondria
Mitochondrion Organization
Mitochondrial Outer Membrane
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Channel Activity
Bcl-2 Family Protein Complex
Intrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
BH3 Domain Binding
Negative Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Programmed Cell Death
Regulation Of Membrane Permeability
Pore Complex
Apoptotic Process
Mitochondrial Membrane
Programmed Cell Death
Cell Death
Mitochondrial Membrane Organization
Mitochondrion
Mitochondrial Fusion
Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Regulation Of Mitochondrial Membrane Potential
Regulation Of Programmed Cell Death
Positive Regulation Of Mitochondrial Membrane Permeability
Cellular Response To Stress
Positive Regulation Of Membrane Permeability
Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Intrinsic Apoptotic Signaling Pathway
DNA Damage Response
Negative Regulation Of Autophagy
Intracellular Signal Transduction
Neuron Apoptotic Process
Regulation Of Autophagy
Regulation Of Release Of Cytochrome C From Mitochondria
Transmembrane Transport
Epithelial Cell Apoptotic Process
Ovarian Follicle Development
Mononuclear Cell Proliferation
Leukocyte Apoptotic Process
Response To Gamma Radiation
Leukocyte Proliferation
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?