BID and CSNK2A2

Number of citations of the paper that reports this interaction (PubMedID 11583622)
0

Data Source:
HPRD (in vitro, in vivo)

		BID	CSNK2A2
Description		BH3 interacting domain death agonist	casein kinase 2 alpha 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Cytosol Protein Kinase CK2 Complex PcG Protein Complex
	Molecular Function	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Stress Intracellular Signal Transduction Regulation Of T Cell Proliferation Signal Transduction In Response To DNA Damage Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Epithelial Cell Proliferation Neuron Apoptotic Process Protein-containing Complex Assembly Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Supramolecular Fiber Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Double-strand Break Repair Apoptotic Process DNA Damage Response Spermatogenesis Wnt Signaling Pathway Cerebral Cortex Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Liver Regeneration Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Diisocyanate-induced asthma ( 25918132) Platelet count ( 32888494) Plateletcrit ( 32888494)	Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)
Interacting Genes		36 interacting genes: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DDIT4L ERG28 FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL SETDB1 TLE1 TUBB2B YWHAB ZHX1	104 interacting genes: ABCA1 ACACA ADH1A AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CEBPA CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GRIN2A GRIN2B GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		637	1459
HPRD ID		03590	00279
Ensembl ID		ENSG00000015475	ENSG00000070770
Uniprot IDs		A8ASI8 B2ZP79 B3KT21 P55957	P19784
PDB IDs		1ZY3 2BID 2KBW 2M5B 2M5I 4BD2 4QVE 4ZEQ 4ZIG 4ZII 5AJJ 5C3F 7M5A 7M5B 7P33 7QTW 8SM5	3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU 7A1B 7A1Z 7A22 7A2H 7AT9 7ATV 7XYH 8Q77 8Q9S 8QBU 8QCD 8QCG 8QF1
Enriched GO Terms of Interacting Partners?		Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Release Of Cytochrome C From Mitochondria Apoptotic Process Cell Death Programmed Cell Death Channel Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Execution Phase Of Apoptosis Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Protein Kinase CK2 Complex Mitochondrial Outer Membrane Cysteine-type Peptidase Activity Regulation Of Apoptotic Process Protein Maturation Regulation Of Programmed Cell Death Identical Protein Binding Leukocyte Apoptotic Process DNA Damage Response Regulation Of Neuron Apoptotic Process Mitochondrial Fusion Negative Regulation Of Anoikis Regulation Of Autophagy Signal Transduction Programmed Cell Death Involved In Cell Development Response To Cytokine Response To Peptide Negative Regulation Of Programmed Cell Death Regulation Of Anoikis Cysteine-type Endopeptidase Activity Peptidase Activity B Cell Homeostasis Cytosol Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Mitochondrion Organization Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Response To Stress B Cell Apoptotic Process Pyroptotic Inflammatory Response	Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Enzyme Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Alcohol Regulation Of Signal Transduction Regulation Of Metabolic Process Macromolecule Metabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Stress Response To Alkaloid Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of RNA Metabolic Process
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