CCL22 and CRYAB

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CCL22	CRYAB
Name		C-C motif chemokine ligand 22	crystallin alpha B
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Surface Z Disc Axon M Band I Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Contractile Muscle Fiber Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Cytoskeletal Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Response To Heat Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	HSF1-dependent transactivation
Diseases		None	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Asthma ( 32296059 ) Blood protein levels ( 30072576 ) Multiple sclerosis ( 24076602 ) Systemic lupus erythematosus ( 28714469 33272962 )	Birth weight ( 31043758 ) Hip circumference adjusted for BMI ( 34021172 ) PR interval ( 32439900 )
Novel Interactors		1 novel interactors: NLGN4X	1 novel interactors: ATM
Interacting Genes		10 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 PF4V1 VCAM1	57 interacting genes: - ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA LBH MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 RBM11 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TIAM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		6367	1410
HPRD ID		04263	00428
Ensembl ID		ENSG00000102962	ENSG00000109846
Uniprot IDs		O00626	A0A024R3B9 P02511 V9HW27
PDB IDs		Not available	2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9 7ROJ 9BEE
GO Terms Enriched among Interactors		Chemotaxis Locomotion Cell Chemotaxis Chemokine Activity Cell Migration Inflammatory Response Chemokine-mediated Signaling Pathway Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response Response To Stress Antimicrobial Humoral Response CCR Chemokine Receptor Binding Regulation Of Neutrophil Chemotaxis Cytokine Activity Regulation Of Neutrophil Migration T Cell Costimulation Nitrate Transmembrane Transporter Activity Immune System Process Cell Surface Positive Regulation Of T Cell Activation Regulation Of Granulocyte Chemotaxis Glucagon Processing Regulation Of Cell Activation Humoral Immune Response Positive Regulation Of Dendritic Cell Dendrite Assembly Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Hypoxia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Extracellular Region Response To Lipid Response To Oxygen Levels Response To Decreased Oxygen Levels Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Cellular Response To Thyroxine Stimulus Negative Regulation Of Hepatic Stellate Cell Activation Glutamate-cysteine Ligase Activity Glutamate-cysteine Ligase Complex Granulocyte Chemotaxis CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Peripheral Nervous System Neuron Differentiation Response To Heat Granulocyte Migration Cell Adhesion Molecule Binding Regulation Of Leukocyte Cell-cell Adhesion	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Identical Protein Binding System Process Protein Refolding Regulation Of Transport Response To Metal Ion Regulation Of Autophagy Response To Heat Sensory Perception Regulation Of Multicellular Organismal Process Nervous System Process Apoptotic Process Programmed Cell Death Cellular Response To Metal Ion Positive Regulation Of Growth Cell Death Response To Oxidative Stress Visual Perception Sensory Perception Of Light Stimulus Regulation Of Growth Response To Copper Ion Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Z Disc Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Cellular Response To Stress Response To Unfolded Protein Positive Regulation Of Apoptotic Process Response To Temperature Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Programmed Cell Death Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Endocytosis Cytosol Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Reactive Oxygen Species Positive Regulation Of Cell Growth Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Ovarian Follicle Development