Wiki-Pi
About
Search
People
Updates
Search
CCL22 and HERC3
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
CCL22
HERC3
Description
C-C motif chemokine ligand 22
HECT and RLD domain containing E3 ubiquitin protein ligase 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Cytoplasmic Vesicle
Molecular Function
Cytokine Activity
Protein Binding
Chemokine Activity
CCR Chemokine Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Biological Process
Chemotaxis
Inflammatory Response
Immune Response
Signal Transduction
Cell-cell Signaling
Response To Virus
Positive Regulation Of Cell Migration
Killing Of Cells Of Another Organism
Eosinophil Chemotaxis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemokine-mediated Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Pathways
Chemokine receptors bind chemokines
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Asthma (
32296059
)
Blood protein levels (
30072576
)
Multiple sclerosis (
24076602
)
Systemic lupus erythematosus (
28714469
33272962
)
A body shape index (
34021172
)
Hair greying (
26926045
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
26426971
34021172
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
10 interacting genes:
AQP6
CCL14
CCL19
CCR4
CRYAB
DPP4
GCLC
HERC3
PF4V1
VCAM1
17 interacting genes:
BTRC
CCL22
CD33
EIF5A2
HERC6
MAPK1
NME2
RPL23A
SRPK2
TK1
TRIM14
UBA52
UBC
UBE2D1
UBE2L3
UBQLN1
UBQLN2
Entrez ID
6367
8916
HPRD ID
04263
16093
Ensembl ID
ENSG00000102962
ENSG00000138641
Uniprot IDs
O00626
B4DK41
H0Y8G9
Q15034
PDB IDs
Enriched GO Terms of Interacting Partners
?
Chemotaxis
Locomotion
Cell Chemotaxis
Chemokine Activity
Cell Migration
Inflammatory Response
Chemokine-mediated Signaling Pathway
Cell Motility
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Defense Response
Response To Stress
Antimicrobial Humoral Response
CCR Chemokine Receptor Binding
Regulation Of Neutrophil Chemotaxis
Cytokine Activity
Regulation Of Neutrophil Migration
T Cell Costimulation
Nitrate Transmembrane Transporter Activity
Immune System Process
Cell Surface
Positive Regulation Of T Cell Activation
Regulation Of Granulocyte Chemotaxis
Glucagon Processing
Regulation Of Cell Activation
Humoral Immune Response
Positive Regulation Of Dendritic Cell Dendrite Assembly
Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
Cardiac Neuron Differentiation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Response To Hypoxia
PH-gated Chloride Channel Activity
Nitrate Transmembrane Transport
Extracellular Region
Response To Lipid
Response To Oxygen Levels
Response To Decreased Oxygen Levels
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Cellular Response To Thyroxine Stimulus
Negative Regulation Of Hepatic Stellate Cell Activation
Glutamate-cysteine Ligase Activity
Glutamate-cysteine Ligase Complex
Granulocyte Chemotaxis
CCR7 Chemokine Receptor Binding
CCL19-activated CCR7 Signaling Pathway
Peripheral Nervous System Neuron Differentiation
Response To Heat
Granulocyte Migration
Cell Adhesion Molecule Binding
Regulation Of Leukocyte Cell-cell Adhesion
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Protein Modification Process
Positive Regulation Of Protein Metabolic Process
Macromolecule Metabolic Process
Proteolysis
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Cytosol
Protein Modification By Small Protein Conjugation
Pyrimidine-containing Compound Metabolic Process
Cytoplasm
Protein Tag Activity
Mammary Gland Epithelial Cell Proliferation
Autophagosome Assembly
Autophagosome Organization
Positive Regulation Of ERAD Pathway
Positive Regulation Of Protein Ubiquitination
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Catabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of ERAD Pathway
Ubiquitin Protein Ligase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Ubiquitin Conjugating Enzyme Activity
Positive Regulation Of Metabolic Process
Vacuole Organization
Polyubiquitin Modification-dependent Protein Binding
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Pyrimidine-containing Compound Biosynthetic Process
Transferase Activity
Regulation Of Protein Ubiquitination
Mitochondrial Outer Membrane
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Store-operated Calcium Channel Activity
Proteasomal Protein Catabolic Process
Cytosolic Large Ribosomal Subunit
ATP Binding
ITP Biosynthetic Process
Protein Histidine Kinase Activity
Cytosine Metabolic Process
Cellular Response To Nutrient Levels
Thymidine Kinase Activity
Negative Regulation Of TORC1 Signaling
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?