CCL22 and CCL14

Number of citations: 0 (PubMedID 28381538)
Data Source: BioGRID (pull down)

		CCL22	CCL14
Name		C-C motif chemokine ligand 22	C-C motif chemokine ligand 14
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Cytokine Activity Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Intracellular Calcium Ion Homeostasis Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	None
GWAS		Asthma ( 32296059 ) Blood protein levels ( 30072576 ) Multiple sclerosis ( 24076602 ) Systemic lupus erythematosus ( 28714469 33272962 )	Blood protein levels ( 30072576 ) Metabolite levels ( 23823483 ) Upper eyelid sagging severity ( 24869959 )
Interacting Genes		10 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 PF4V1 VCAM1	12 interacting genes: ACKR2 AKT2 CCL11 CCL22 CCR1 CCR3 CCR5 DDX39A EXOSC8 NOA1 PIK3R1 RBPMS
Entrez ID		6367	6358
HPRD ID		04263	03231
Ensembl ID		ENSG00000102962	ENSG00000276409
Uniprot IDs		O00626	Q16627
PDB IDs		Not available	2Q8R 2Q8T
GO Terms Enriched among Interactors		Chemotaxis Locomotion Cell Chemotaxis Chemokine Activity Cell Migration Inflammatory Response Chemokine-mediated Signaling Pathway Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response Response To Stress Antimicrobial Humoral Response CCR Chemokine Receptor Binding Regulation Of Neutrophil Chemotaxis Cytokine Activity Regulation Of Neutrophil Migration T Cell Costimulation Nitrate Transmembrane Transporter Activity Immune System Process Cell Surface Positive Regulation Of T Cell Activation Regulation Of Granulocyte Chemotaxis Glucagon Processing Regulation Of Cell Activation Humoral Immune Response Positive Regulation Of Dendritic Cell Dendrite Assembly Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Hypoxia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Extracellular Region Response To Lipid Response To Oxygen Levels Response To Decreased Oxygen Levels Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Cellular Response To Thyroxine Stimulus Negative Regulation Of Hepatic Stellate Cell Activation Glutamate-cysteine Ligase Activity Glutamate-cysteine Ligase Complex Granulocyte Chemotaxis CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Peripheral Nervous System Neuron Differentiation Response To Heat Granulocyte Migration Cell Adhesion Molecule Binding Regulation Of Leukocyte Cell-cell Adhesion	Chemokine-mediated Signaling Pathway Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Cytokine-mediated Signaling Pathway Chemotaxis Locomotion Intracellular Signal Transduction Leukocyte Migration Chemokine (C-C Motif) Ligand 5 Binding Intracellular Signaling Cassette Cell Migration Inflammatory Response Myeloid Leukocyte Migration Cell Motility Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Signal Transduction Dendritic Cell Chemotaxis External Side Of Plasma Membrane Eosinophil Chemotaxis G Protein-coupled Receptor Activity Eosinophil Migration Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity CCR Chemokine Receptor Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Cell Killing Response To Stress Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of D-glucose Transmembrane Transport Response To Cytokine Response To Peptide Regulation Of Locomotion Chemokine Activity Cellular Defense Response Cellular Response To High Light Intensity Regulation Of Biological Quality