SCNN1G and USP10

Number of citations of the paper that reports this interaction (PMID 18632802)
10

Data Source:
HPRD (in vivo)

		SCNN1G	USP10
Gene Name		sodium channel, non voltage gated 1 gamma subunit	ubiquitin specific peptidase 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm Early Endosome
	Molecular Function	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Ion Channel Binding Poly(A) RNA Binding
	Biological Process	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis Transmembrane Transport	DNA Repair Autophagy Regulation Of Autophagy Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Ion channel transport Stimuli-sensing channels
Drugs		Triamterene Amiloride
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		11 interactors: EPN1 MAPK1 NEDD4 NEDD4L SCNN1A SCNN1B SCNN1D SERP1 STX1A USP10 WWP2	9 interactors: AR G3BP1 G3BP2 IKBKG SCNN1A SCNN1G SNX3 TP53 UBC
Entrez ID		6340	9100
HPRD ID		02862	07029
Ensembl ID		ENSG00000166828	ENSG00000103194
Uniprot IDs		A5X2V1 P51170	Q14694
PDB IDs
Enriched GO Terms of Interacting Partners?		Sodium Ion Homeostasis Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport Excretion Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Water Homeostasis Sensory Perception Of Taste Sodium Ion Transport Regulation Of Membrane Potential Negative Regulation Of Sodium Ion Transport Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Localization Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Sodium Ion Transmembrane Transport Protein K63-linked Ubiquitination Protein Catabolic Process Negative Regulation Of Transporter Activity Protein Monoubiquitination Monovalent Inorganic Cation Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Stimulus Proteasomal Protein Catabolic Process Multicellular Organismal Water Homeostasis Positive Regulation Of Transport Regulation Of Protein Localization Sensory Perception Metal Ion Transport Regulation Of Sodium Ion Transport Cellular Macromolecule Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Positive Regulation Of Translation Regulation Of Vesicle-mediated Transport Regulation Of Protein Catabolic Process Negative Regulation Of Transport Ion Transport Sensory Perception Of Chemical Stimulus Regulation Of Ion Transmembrane Transport Negative Regulation Of Ion Transport MAPK Import Into Nucleus	Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Transport Sodium Ion Homeostasis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ras Protein Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of Establishment Of Protein Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Localization Excretion Multicellular Organismal Water Homeostasis Regulation Of Wnt Signaling Pathway Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Toll-like Receptor 10 Signaling Pathway Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction Involved In DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Programmed Cell Death Water Homeostasis TRIF-dependent Toll-like Receptor Signaling Pathway Sensory Perception Of Taste MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator
Tagcloud ?		adherens aqp2 aqp3 bioinformatic collecting crebbp ctnnb1 duct elf3 enacbeta enacgamma esbl flanking gatad2b gov helixweb hmbox1 http hypotheses isotope junb junctions mnpd mpkccd nih pser552 rangap1 vasopressin	bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10
Tagcloud (Difference) ?		adherens aqp2 aqp3 collecting crebbp ctnnb1 duct elf3 enacbeta enacgamma esbl flanking gatad2b gov helixweb hmbox1 http hypotheses isotope junb junctions mnpd mpkccd nih pser552 rangap1 vasopressin	class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10
Tagcloud (Intersection) ?		bioinformatic