SCNN1G and USP10

Number of citations of the paper that reports this interaction (PubMedID 18632802)
0

Data Source:
HPRD (in vivo)

		SCNN1G	USP10
Description		sodium channel epithelial 1 subunit gamma	ubiquitin specific peptidase 10
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytosolic Ribosome Protein-containing Complex Intermediate Filament Cytoskeleton
	Molecular Function	Monoatomic Ion Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Transmembrane Transporter Binding Molecular Function Inhibitor Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Sodium Ion Homeostasis Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin	DNA Repair Chromatin Remodeling Proteolysis Protein Monoubiquitination Autophagy DNA Damage Response Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Stress Granule Assembly Monoubiquitinated Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Stress Granule Assembly Cellular Response To Interleukin-1 Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Stimuli-sensing channels Sensory perception of salty taste	Termination of translesion DNA synthesis Ub-specific processing proteases
Drugs		Triamterene Amiloride
Diseases		Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Heel bone mineral density ( 30598549) Parent of origin effect on receptive language ability (paternal) ( 32635940)	Appendicular lean mass ( 33097823) Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		13 interacting genes: COMMD10 EPN1 MAPK1 NEDD4 NEDD4L SCNN1A SCNN1B SCNN1D SERP1 SOX4 STX1A USP10 WWP2	32 interacting genes: AKT1 ANLN AR AXIN1 CCND3 CFTR CTNNB1 DAAM1 FSCN1 FZR1 G3BP1 G3BP2 H2AC20 HDAC6 HNRNPLL KLF4 LINC00460 MAP1LC3B MSH2 NOTCH1 PABPC1 PCGF5 RAD51 RUNX1 SCNN1A SCNN1G SMAD4 SNX3 SOX21-AS1 TRNAU1AP UBC ZBTB7A
Entrez ID		6340	9100
HPRD ID		02862	07029
Ensembl ID		ENSG00000166828	ENSG00000103194
Uniprot IDs		A5X2V1 P51170	A0A7G6J4N4 Q14694
PDB IDs		6BQN 6WTH 9BLR 9BTG 9BTU	7XHF 8TH6
Enriched GO Terms of Interacting Partners?		Import Into Cell Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Transmembrane Transporter Binding Potassium Channel Inhibitor Activity Regulation Of Biological Quality Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Sodium Ion Transport Response To Aldosterone Cellular Response To Acidic PH Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Response To Acidic PH Cellular Response To PH Negative Regulation Of Potassium Ion Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Transmembrane Transport Sodium Ion Homeostasis Response To Mineralocorticoid Response To PH Import Across Plasma Membrane Protein Monoubiquitination Endocytosis Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Chemical Homeostasis Cellular Response To Steroid Hormone Stimulus Regulation Of Potassium Ion Transport Negative Regulation Of Sodium Ion Transport Metal Ion Transport Negative Regulation Of Monoatomic Ion Transport Regulation Of Transport Protein Modification Process Sensory Perception Of Chemical Stimulus Cellular Homeostasis Negative Regulation Of Transmembrane Transport Receptor Catabolic Process Protein Modification By Small Protein Conjugation	Transcription Corepressor Binding Positive Regulation Of Cellular Component Organization Enzyme Binding Response To Alcohol Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Cellular Response To Oxygen-containing Compound Cellular Response To Hormone Stimulus Response To Ketone Negative Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of RNA Metabolic Process In Utero Embryonic Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Proliferation Involved In Heart Morphogenesis Chordate Embryonic Development Positive Regulation Of Gene Expression Epithelial Cell Differentiation Regulation Of Extracellular Matrix Organization Negative Regulation Of Metabolic Process Response To Lipid Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Axis Specification Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Cell Cortex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Negative Regulation Of Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Organelle Assembly Positive Regulation Of Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Endocardial Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Beta-catenin Binding Response To Mineralocorticoid Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Protein-containing Complex
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