IL27 and IL27RA

Number of citations of the paper that reports this interaction (PMID 12121660)
208

Data Source:
HPRD (in vitro, in vivo)

		IL27	IL27RA
Gene Name		interleukin 27	interleukin 27 receptor, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Cytokine Activity Interleukin-27 Receptor Binding	Transmembrane Signaling Receptor Activity Interleukin-27 Receptor Activity
	Biological Process	Inflammatory Response Response To Bacterium Regulation Of T Cell Proliferation Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Regulation Of T-helper 1 Cell Differentiation Regulation Of Defense Response To Virus	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Type 1 diabetes ( 19430480) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		1 interactors: IL27RA	4 interactors: EBI3 IL27 MAPK8 STAT1
Entrez ID		246778	9466
HPRD ID		16307	09247
Ensembl ID		ENSG00000197272	ENSG00000104998
Uniprot IDs		Q8NEV9	Q6UWB1
PDB IDs
Enriched GO Terms of Interacting Partners?		Interleukin-27-mediated Signaling Pathway Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Regulation Of Isotype Switching Regulation Of Type 2 Immune Response Positive Regulation Of Interferon-gamma Production Defense Response To Gram-positive Bacterium Regulation Of DNA Recombination Regulation Of Interferon-gamma Production Negative Regulation Of Immune Response Positive Regulation Of Adaptive Immune Response Defense Response To Bacterium Regulation Of Adaptive Immune Response Positive Regulation Of Cytokine Production Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Response To Bacterium Regulation Of Cytokine Production Cellular Response To Cytokine Stimulus	Positive Regulation Of Interferon-gamma Biosynthetic Process Immune Response Regulation Of Immune System Process Positive Regulation Of Interferon-gamma Production Response To Bacterium Positive Regulation Of Cytokine Biosynthetic Process Immune System Process Regulation Of Interferon-gamma Production Response To Other Organism Response To Biotic Stimulus Regulation Of Cytokine Biosynthetic Process Innate Immune Response Response To Hydrogen Peroxide Negative Regulation Of Macrophage Fusion Regulation Of Immune Response Regulation Of T Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Response To Reactive Oxygen Species Positive Regulation Of Metabolic Process Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Response To Mechanical Stimulus Regulation Of Innate Immune Response Defense Response JUN Phosphorylation Metanephric Mesenchymal Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Deacetylase Activity Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipopolysaccharide Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Lymphocyte Activation Response To External Stimulus Regulation Of T-helper 1 Cell Differentiation Cell Proliferation Involved In Metanephros Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cellular Response To Lipid Response To Oxidative Stress
Tagcloud ?		antiviral candidates chemokines defense delineates derives genetics hairpin herpes hsv identifies ifns immunity infectivity irf3 loci predisposed proinflammatory raw screen shrnas simplex synergistically t1d tagap throughput transduced unbiased uncharacterized	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?		antiviral candidates chemokines defense delineates derives genetics hairpin herpes hsv identifies ifns immunity infectivity irf3 loci predisposed proinflammatory raw screen shrnas simplex synergistically t1d tagap throughput transduced unbiased uncharacterized	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?