IL27

Name	interleukin 27
Structure
Interactors	3 interactors: IL27RA S100A6 S100P
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cytosol Cell Surface
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Interleukin-27 Receptor Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Immune System Process Inflammatory Response Signal Transduction Response To Bacterium Positive Regulation Of Type II Interferon Production Regulation Of T Cell Proliferation Innate Immune Response Regulation Of T-helper 1 Cell Differentiation Regulation Of Defense Response To Virus Regulation Of T Cell Activation Response To Gram-positive Bacterium
Pathways	Interleukin-27 signaling Interleukin-27 signaling
GWAS	Allergic disease (asthma, hay fever or eczema) ( 29679657 ) Ankylosing spondylitis ( 23749187 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 29273807 28892062 ) Brain morphology (MOSTest) ( 32665545 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic obstructive pulmonary disease ( 28166215 ) Crohn's disease ( 28067908 30500874 32581322 21102463 ) Extremely high intelligence ( 29520040 ) FEV1 ( 30804560 ) General cognitive ability ( 29844566 ) Household income (MTAG) ( 31844048 ) Inflammatory bowel disease ( 28067908 23128233 ) Inflammatory bowel disease (early onset) ( 19915574 ) Intelligence (MTAG) ( 29326435 ) Lamb consumption ( 32066663 ) Lung function (FVC) ( 30804560 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Plateletcrit ( 32888494 ) Red cell distribution width ( 32888494 ) Type 1 diabetes ( 25751624 21829393 19430480 )
Entrez ID	246778
HPRD ID	16307
Ensembl ID	ENSG00000197272
Uniprot IDs	Q8NEV9
PDB IDs	7U7N 7ZXK 8D85 8XWY
GO Terms Enriched among Interactors ?	Calcium-dependent Protein Binding Negative Regulation Of T Cell Extravasation Interleukin-27 Receptor Activity Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Transition Metal Ion Binding Negative Regulation Of Lymphocyte Migration Negative Regulation Of Interleukin-17 Production Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Migration Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Cellular Extravasation Negative Regulation Of Type 2 Immune Response Calcium Ion Binding Protein Homodimerization Activity Microvillus Membrane Regulation Of Isotype Switching Regulation Of Type 2 Immune Response Regulation Of T-helper 17 Type Immune Response Regulation Of Cellular Extravasation Negative Regulation Of Mononuclear Cell Migration