AGER and TTR

Number of citations of the paper that reports this interaction (PMID 16716307)
8

Data Source:
HPRD (in vitro)

		AGER	TTR
Gene Name		advanced glycosylation end product-specific receptor	transthyretin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding S100 Protein Binding	Hormone Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity Thyroid Hormone Binding
	Biological Process	Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Wounding Neuron Projection Development Innate Immune Response Induction Of Positive Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity	Retinoid Metabolic Process Transport Phototransduction, Visible Light Extracellular Matrix Organization Retinol Metabolic Process Thyroid Hormone Transport
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Amyloids Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Non-integrin membrane-ECM interactions Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (interaction) ( 23284291)	Retinol levels ( 21878437)
Protein-Protein Interactions		7 interactors: APP HMGB1 S100A1 S100A12 S100B S100P TTR	46 interactors: A2M ACTB AGER APOA1 ASNA1 ATF4 BAG6 C14orf1 CDR2 CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 FEZ1 GET4 HNRNPH3 HSPG2 IKBKAP INPP5K KIAA1377 LRP2 MARK3 MT3 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1
Entrez ID		177	7276
HPRD ID		02568	01447
Ensembl ID		ENSG00000204305	ENSG00000118271
Uniprot IDs		B4DNX3 Q15109 Q3L1S0	E9KL36 P02766
PDB IDs		1PWI 2BJP 2E5E 2ENS 2L7U 2LE9 2LMB 3CJJ 3O3U 3S58 3S59	1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 5TTR
Enriched GO Terms of Interacting Partners?		Innate Immune Response Locomotion Immune Response Negative Regulation Of Apoptotic Cell Clearance Defense Response Leukocyte Chemotaxis Movement Of Cell Or Subcellular Component Chemotaxis Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Synaptic Growth At Neuromuscular Junction Response To Stimulus Cell Activation Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Response To External Stimulus Cell Chemotaxis Negative Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neuron Projection Development Cell Migration Collateral Sprouting Axon Midline Choice Point Recognition Base-excision Repair, DNA Ligation Thyroid Hormone Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cell Motility Leukocyte Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Axon Choice Point Recognition Neuron Development Central Nervous System Development Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Nervous System Development Regulation Of Binding Cellular Response To Stimulus Learning Or Memory Neuron Remodeling Response To Abiotic Stimulus Response To Methylmercury DNA Ligation Involved In DNA Repair Cognition Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Cell Clearance Neuron Differentiation Cell Projection Organization	Protein Insertion Into ER Membrane Anatomical Structure Development Developmental Process Protein Stabilization Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Protein Stability Nervous System Development Central Nervous System Development Regulation Of Gene Expression Protein Insertion Into Membrane System Development Cellular Localization Phototransduction, Visible Light Retinoid Metabolic Process Detection Of Abiotic Stimulus Diterpenoid Metabolic Process Detection Of Visible Light Cellular Response To Stimulus Platelet Activation Phototransduction Response To Light Stimulus Chromatin Organization Regulation Of Glucose Transport Alcohol Metabolic Process Detection Of Light Stimulus Organelle Organization Establishment Of Protein Localization To Membrane Metabolic Process Lipid Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Cellular Metabolic Process Isoprenoid Metabolic Process Response To Organic Substance Endoplasmic Reticulum Organization Chromatin Modification Regulation Of Cellular Protein Metabolic Process Membrane Organization Response To Radiation Negative Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Response To Wounding Signaling Regulation Of Glucose Import Cellular Protein Modification Process
Tagcloud ?		algorithm attributable cerebrovascular combine constructed enrichment go iia illuminate incompletely ingredients interesting markov mcl miltiorrhiza module modules network nodes ontology partly pin salvia tan tanshinone toll traf2 traf3 traf6	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Difference) ?		algorithm attributable cerebrovascular combine constructed enrichment go iia illuminate incompletely ingredients interesting markov mcl miltiorrhiza module modules network nodes ontology partly pin salvia tan tanshinone toll traf2 traf3 traf6	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Intersection) ?