AGER and HMGB1

Number of citations of the paper that reports this interaction (PMID 9812979)
8

Data Source:
HPRD (in vitro)

		AGER	HMGB1
Gene Name		advanced glycosylation end product-specific receptor	high mobility group box 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Cell Surface Transcriptional Repressor Complex
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding S100 Protein Binding	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Cytokine Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Chemoattractant Activity Poly(A) RNA Binding RAGE Receptor Binding Repressing Transcription Factor Binding
	Biological Process	Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Wounding Neuron Projection Development Innate Immune Response Induction Of Positive Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Dendritic Cell Activation Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation DNA Recombination Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Neuron Projection Development V(D)J Recombination Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Chemotaxis DNA Ligation Involved In DNA Repair Negative Regulation Of Apoptotic Cell Clearance
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Activation of DNA fragmentation factor Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Programmed Cell Death MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Apoptotic execution phase MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Apoptosis induced DNA fragmentation Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (interaction) ( 23284291)	MRI atrophy measures ( 21116278)
Protein-Protein Interactions		7 interactors: APP HMGB1 S100A1 S100A12 S100B S100P TTR	73 interactors: AES AGER AGTRAP AR ATOH1 C14orf1 CASP3 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CUX1 DNM2 DNMT1 ERF FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HR IRF2 LRIF1 MECP2 MNT NCAN NEUROD6 NFKB1 NR3C1 PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 SIX5 SOX18 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLR2 TLR4 TP53 TP73 UNC119 ZFP36 ZNF24
Entrez ID		177	3146
HPRD ID		02568	01228
Ensembl ID		ENSG00000204305	ENSG00000189403
Uniprot IDs		B4DNX3 Q15109 Q3L1S0	P09429 Q5T7C4
PDB IDs		1PWI 2BJP 2E5E 2ENS 2L7U 2LE9 2LMB 3CJJ 3O3U 3S58 3S59	2LY4 2YRQ
Enriched GO Terms of Interacting Partners?		Innate Immune Response Locomotion Immune Response Negative Regulation Of Apoptotic Cell Clearance Defense Response Leukocyte Chemotaxis Movement Of Cell Or Subcellular Component Chemotaxis Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Synaptic Growth At Neuromuscular Junction Response To Stimulus Cell Activation Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Response To External Stimulus Cell Chemotaxis Negative Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neuron Projection Development Cell Migration Collateral Sprouting Axon Midline Choice Point Recognition Base-excision Repair, DNA Ligation Thyroid Hormone Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cell Motility Leukocyte Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Axon Choice Point Recognition Neuron Development Central Nervous System Development Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Nervous System Development Regulation Of Binding Cellular Response To Stimulus Learning Or Memory Neuron Remodeling Response To Abiotic Stimulus Response To Methylmercury DNA Ligation Involved In DNA Repair Cognition Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Cell Clearance Neuron Differentiation Cell Projection Organization	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cellular Process System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Anterior/posterior Pattern Specification Regulation Of Cell Differentiation Pattern Specification Process
Tagcloud ?		algorithm attributable cerebrovascular combine constructed enrichment go iia illuminate incompletely ingredients interesting markov mcl miltiorrhiza module modules network nodes ontology partly pin salvia tan tanshinone toll traf2 traf3 traf6	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated
Tagcloud (Difference) ?		algorithm attributable cerebrovascular combine constructed enrichment go iia illuminate incompletely ingredients interesting markov mcl miltiorrhiza module modules network nodes ontology partly pin salvia tan tanshinone toll traf2 traf3 traf6	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated
Tagcloud (Intersection) ?