AGER and S100A12

Number of citations of the paper that reports this interaction (PubMedID 10399917)
0

Data Source:
HPRD (in vivo, in vitro)

		AGER	S100A12
Description		advanced glycosylation end-product specific receptor	S100 calcium binding protein A12
Image
GO Annotations	Cellular Component	Fibrillar Center Phagocytic Cup Extracellular Region Nucleus Endosome Early Endosome Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cell Junction Cell Projection Postsynapse	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Secretory Granule Lumen
	Molecular Function	Amyloid-beta Binding DNA Binding RNA Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Laminin Receptor Activity Protein Binding Signaling Receptor Activity Histone Binding Identical Protein Binding S100 Protein Binding Protein-containing Complex Binding Advanced Glycation End-product Receptor Activity Molecular Adaptor Activity	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Response To Hypoxia Microglial Cell Activation Positive Regulation Of Cytokine Production Regulation Of T Cell Mediated Cytotoxicity DNA Replication DNA Repair Phagocytosis Inflammatory Response DNA Damage Response Cell Adhesion Cell Surface Receptor Signaling Pathway Learning Or Memory Positive Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Biosynthetic Process Glucose Mediated Signaling Pathway Astrocyte Development Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Activated T Cell Proliferation Transcytosis Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Synaptic Plasticity Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Positive Regulation Of DNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Protein Localization To Membrane Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Regulation Of P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Circulation Positive Regulation Of Endothelin Production Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Response To Amyloid-beta Cellular Response To Amyloid-beta Positive Regulation Of DNA-templated DNA Replication Positive Regulation Of Monocyte Extravasation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Double-strand Break Repair Positive Regulation Of Dendritic Cell Differentiation	Immune System Process Monocyte Chemotaxis Xenobiotic Metabolic Process Inflammatory Response Neutrophil Chemotaxis Killing Of Cells Of Another Organism Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAP Kinase Activity Endothelial Cell Migration Innate Immune Response Mast Cell Activation Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		TAK1-dependent IKK and NF-kappa-B activation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	TAK1-dependent IKK and NF-kappa-B activation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs			Olopatadine Amlexanox
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels in cardiovascular risk ( 28369058) Chronic obstructive pulmonary disease ( 33909500 30804561 28166215) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Percentage gas trapping ( 26030696) Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Response to Pazopanib in cancer (hepatotoxicity) ( 26546620) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Soluble receptor for advanced glycation end-product levels ( 26083729) Ulcerative colitis ( 28067908)	Asthma ( 31619474) Blood protein levels ( 30072576) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		10 interacting genes: APP C3orf52 CMTM7 CREB3 HMGB1 S100A1 S100A12 S100B S100P TTR	3 interacting genes: AGER CACYBP TNF
Entrez ID		177	6283
HPRD ID		02568	04383
Ensembl ID		ENSG00000204305	ENSG00000163221
Uniprot IDs		A0A1U9X785 B4DNX3 Q101R3 Q15109	P80511
PDB IDs		2E5E 2ENS 2L7U 2LE9 2LMB 2M1K 2MJW 2MOV 3CJJ 3O3U 4LP4 4LP5 4OF5 4OFV 4OI7 4OI8 4P2Y 4XYN 4YBH 5D7F 6VXG 6XQ1 6XQ3 6XQ5 6XQ6 6XQ7 6XQ8 6XQ9 7LML 7LMW 8I9M	1E8A 1GQM 1ODB 2M9G 2WC8 2WCB 2WCE 2WCF
Enriched GO Terms of Interacting Partners?		RAGE Receptor Binding Calcium-dependent Protein Binding Positive Regulation Of Monocyte Chemotaxis Chemotaxis Regulation Of Monocyte Chemotaxis Locomotion Identical Protein Binding Endothelial Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Protein Homodimerization Activity S100 Protein Binding Extracellular Region Secretory Granule Lumen Myeloid Leukocyte Activation Transition Metal Ion Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Sprouting Angiogenesis Chemoattractant Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Chemotaxis Regulation Of System Process Leukocyte Activation Regulation Of Leukocyte Migration Calcium Ion Binding Positive Chemotaxis Cell Activation Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Fungus Response To Fungus Positive Regulation Of Interleukin-1 Beta Production Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Sprouting Angiogenesis Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Deacetylase Activity Macrophage Activation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Extracellular Space Acetylcholine Receptor Activator Activity	Positive Regulation Of Heterotypic Cell-cell Adhesion Astrocyte Activation S100 Protein Binding Negative Regulation Of Blood Circulation Phagocytic Cup Positive Regulation Of DNA Metabolic Process Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Cytokine Production Positive Regulation Of DNA Replication Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Macrophage Activation Response To Amyloid-beta Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction SCF Ubiquitin Ligase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Activation Cellular Response To Amino Acid Stimulus Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Advanced Glycation End-product Receptor Activity Cell Activation Regulation Of Interleukin-1 Beta Production Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Response To Hormone Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Interleukin-1 Production Regulation Of DNA Replication Response To Amino Acid Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process DNA Damage Response Positive Regulation Of Synaptic Transmission Myeloid Leukocyte Activation
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