AGER and S100P

Number of citations of the paper that reports this interaction (PMID 14617629)
53

Data Source:
HPRD (in vivo)

		AGER	S100P
Gene Name		advanced glycosylation end product-specific receptor	S100 calcium binding protein P
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Cytoplasm Microvillus Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding S100 Protein Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Wounding Neuron Projection Development Innate Immune Response Induction Of Positive Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity	Response To Organic Substance Endothelial Cell Migration
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Cromoglicic acid
Diseases
GWAS		Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (interaction) ( 23284291)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: APP HMGB1 S100A1 S100A12 S100B S100P TTR	12 interactors: AGER CACYBP EZR S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11
Entrez ID		177	6286
HPRD ID		02568	02792
Ensembl ID		ENSG00000204305
Uniprot IDs		B4DNX3 Q15109 Q3L1S0	P25815
PDB IDs		1PWI 2BJP 2E5E 2ENS 2L7U 2LE9 2LMB 3CJJ 3O3U 3S58 3S59	1J55 1OZO
Enriched GO Terms of Interacting Partners?		Innate Immune Response Locomotion Immune Response Negative Regulation Of Apoptotic Cell Clearance Defense Response Leukocyte Chemotaxis Movement Of Cell Or Subcellular Component Chemotaxis Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Synaptic Growth At Neuromuscular Junction Response To Stimulus Cell Activation Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Response To External Stimulus Cell Chemotaxis Negative Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neuron Projection Development Cell Migration Collateral Sprouting Axon Midline Choice Point Recognition Base-excision Repair, DNA Ligation Thyroid Hormone Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cell Motility Leukocyte Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Axon Choice Point Recognition Neuron Development Central Nervous System Development Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Nervous System Development Regulation Of Binding Cellular Response To Stimulus Learning Or Memory Neuron Remodeling Response To Abiotic Stimulus Response To Methylmercury DNA Ligation Involved In DNA Repair Cognition Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Cell Clearance Neuron Differentiation Cell Projection Organization	Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Spliceosomal Complex Disassembly Negative Regulation Of DNA Recombination At Telomere System Development Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Multicellular Organismal Development Membrane To Membrane Docking Protection From Non-homologous End Joining At Telomere Anatomical Structure Development Regulation Of Cell Shape Telomere Capping Protein Localization To Chromosome, Telomeric Region Ubiquitin-dependent SMAD Protein Catabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Developmental Process Response To Methylmercury Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance
Tagcloud ?		algorithm attributable cerebrovascular combine constructed enrichment go iia illuminate incompletely ingredients interesting markov mcl miltiorrhiza module modules network nodes ontology partly pin salvia tan tanshinone toll traf2 traf3 traf6	adenoma bda bdas bile columnar cuboidal duct ductular ema glut imp indexes interlobular lumen meyenburg morphologic muc1 muc6 narrow ncam nodular peribiliary resembling sclerotic sized stroma uniform vmc von
Tagcloud (Difference) ?		algorithm attributable cerebrovascular combine constructed enrichment go iia illuminate incompletely ingredients interesting markov mcl miltiorrhiza module modules network nodes ontology partly pin salvia tan tanshinone toll traf2 traf3 traf6	adenoma bda bdas bile columnar cuboidal duct ductular ema glut imp indexes interlobular lumen meyenburg morphologic muc1 muc6 narrow ncam nodular peribiliary resembling sclerotic sized stroma uniform vmc von
Tagcloud (Intersection) ?