CNTF and RDM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNTF	RDM1
Description		ciliary neurotrophic factor	RAD52 motif containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Glial Cell Projection	Nucleus Nucleolus Cytoplasm Cytosol Cajal Body PML Body
	Molecular Function	Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Protein-containing Complex Binding	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Astrocyte Activation Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT
Pathways		IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 23128233) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)
Interacting Genes		16 interacting genes: AK8 APOE CNTFR CYSRT1 IL6R IL6ST KRT31 KRT40 LIFR NDUFAB1 RDM1 S100A1 S100A6 S100P TEPSIN TRIP6	5 interacting genes: CCDC57 CNTF MRFAP1L1 RAD52 SCNM1
Entrez ID		1270	201299
HPRD ID		00347	15205
Ensembl ID		ENSG00000242689	ENSG00000278023
Uniprot IDs		P26441	Q8NG50
PDB IDs		1CNT 8D74
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Interleukin-11-mediated Signaling Pathway Cytokine Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Interleukin-6 Receptor Complex Oncostatin-M Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Ciliary Neurotrophic Factor Receptor Binding Regulation Of Platelet Activation Interleukin-6 Receptor Binding Structural Molecule Activity Protein Homodimerization Activity Positive Regulation Of Platelet Aggregation Calcium-dependent Protein Binding T-helper 17 Cell Lineage Commitment S100 Protein Binding Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment External Side Of Plasma Membrane Regulation Of Platelet Aggregation T Cell Lineage Commitment Cytokine-mediated Signaling Pathway Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Receptor Complex Ciliary Neurotrophic Factor Binding Growth Factor Binding Acyl Carrier Activity Coated Vesicle Membrane Vasodilation Structural Constituent Of Skin Epidermis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Presynaptic Membrane Organization	Negative Regulation Of Photoreceptor Cell Differentiation Positive Regulation Of Axon Regeneration Muscle Organ Morphogenesis Regulation Of Retinal Cell Programmed Cell Death Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Retinal Rod Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Double-strand Break Repair Via Single-strand Annealing DNA Recombinase Assembly DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
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