CNTF and NDUFAB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNTF	NDUFAB1
Description		ciliary neurotrophic factor	NADH:ubiquinone oxidoreductase subunit AB1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Glial Cell Projection	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Membrane Respiratory Chain Complex I Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex
	Molecular Function	Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Protein-containing Complex Binding	Acyl Binding Acyl Carrier Activity Structural Molecule Activity Fatty Acid Binding Calcium Ion Binding Protein Binding Mitochondrial Large Ribosomal Subunit Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Astrocyte Activation Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT	Mitochondrial Electron Transport, NADH To Ubiquinone Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Aerobic Respiration Protein Lipoylation Iron-sulfur Cluster Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis [2Fe-2S] Cluster Assembly
Pathways		IL-6-type cytokine receptor ligand interactions	Respiratory electron transport Complex I biogenesis Mitochondrial Fatty Acid Beta-Oxidation Protein lipoylation Mitochondrial ribosome-associated quality control
Drugs			NADH
Diseases
GWAS		Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 23128233) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)	Bipolar disorder ( 17554300)
Interacting Genes		16 interacting genes: AK8 APOE CNTFR CYSRT1 IL6R IL6ST KRT31 KRT40 LIFR NDUFAB1 RDM1 S100A1 S100A6 S100P TEPSIN TRIP6	35 interacting genes: ACTN3 BBC3 BEX5 CCDC24 CNTF EIF3B ERBB3 FEM1A FHL3 FNDC3B HINFP KCTD9 LMO2 LNX1 MBLAC1 MORN3 MRPL23 NOXA1 NRF1 NT5C3A NTAQ1 OIP5 POP5 PPP1R16A PSMC3 RBM18 SLIRP SMYD3 THAP1 TLX3 TOX2 VAC14 ZNF19 ZNF410 ZNF829
Entrez ID		1270	4706
HPRD ID		00347	11951
Ensembl ID		ENSG00000242689	ENSG00000004779
Uniprot IDs		P26441	O14561
PDB IDs		1CNT 8D74	2DNW 5OOL 5OOM 5XTB 5XTC 5XTD 5XTH 5XTI 6ODD 7A5H 7A5J 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF5 7OF7 7OI6 7OI7 7OI8 7OI9 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 8K2B 8PK0 8QSJ 8QU5
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Interleukin-11-mediated Signaling Pathway Cytokine Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Interleukin-6 Receptor Complex Oncostatin-M Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Ciliary Neurotrophic Factor Receptor Binding Regulation Of Platelet Activation Interleukin-6 Receptor Binding Structural Molecule Activity Protein Homodimerization Activity Positive Regulation Of Platelet Aggregation Calcium-dependent Protein Binding T-helper 17 Cell Lineage Commitment S100 Protein Binding Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment External Side Of Plasma Membrane Regulation Of Platelet Aggregation T Cell Lineage Commitment Cytokine-mediated Signaling Pathway Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Receptor Complex Ciliary Neurotrophic Factor Binding Growth Factor Binding Acyl Carrier Activity Coated Vesicle Membrane Vasodilation Structural Constituent Of Skin Epidermis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Presynaptic Membrane Organization
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