CNTF

Gene Name		ciliary neurotrophic factor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm CRLF-CLCF1 Complex
	Molecular Function	Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Growth Factor Activity
	Biological Process	Signal Transduction Positive Regulation Of Cell Proliferation Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Muscle Organ Morphogenesis Neuron Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-protein Interactions		7 interactors: APOE CNTFR IL6R IL6ST KRT40 LIFR TRIP6
Entrez ID		1270
HPRD ID		00347
Ensembl ID		ENSG00000242689
Uniprot IDs		P26441
PDB IDs		1CNT
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Cellular Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Organic Substance Positive Regulation Of JAK-STAT Cascade Signal Transduction Positive Regulation Of Osteoblast Differentiation Signaling Cell Communication Regulation Of JAK-STAT Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Interleukin-11-mediated Signaling Pathway Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Ossification Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Response To Stimulus Hepatic Immune Response Positive Regulation Of Neurofibrillary Tangle Assembly Interleukin-27-mediated Signaling Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phospholipid Efflux Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization
Tagcloud ?		cascades cg ciliary compares converge defines deprived evident extensively feel glia hematopoiesis increasingly jak jak1 neurotrophic ol oligodendrocyte oligodendroglia oligodendroglial pdgf pleiotropic progenitor progenitors responded stat stat1alpha stats trophic