CNTF and CNTFR

Number of citations of the paper that reports this interaction (PubMedID 7810882)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CNTF	CNTFR
Description		ciliary neurotrophic factor	ciliary neurotrophic factor receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Glial Cell Projection	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex Side Of Membrane
	Molecular Function	Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Protein-containing Complex Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding Interleukin-11 Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Astrocyte Activation Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Interleukin-11-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway Motor Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 23128233) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576) Physiological traits ( 31902109)
Interacting Genes		16 interacting genes: AK8 APOE CNTFR CYSRT1 IL6R IL6ST KRT31 KRT40 LIFR NDUFAB1 RDM1 S100A1 S100A6 S100P TEPSIN TRIP6	9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1
Entrez ID		1270	1271
HPRD ID		00347	00348
Ensembl ID		ENSG00000242689	ENSG00000122756
Uniprot IDs		P26441	P26992
PDB IDs		1CNT 8D74	1UC6 8D74 8D7E 8D7H 8D7R
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Interleukin-11-mediated Signaling Pathway Cytokine Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Interleukin-6 Receptor Complex Oncostatin-M Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Ciliary Neurotrophic Factor Receptor Binding Regulation Of Platelet Activation Interleukin-6 Receptor Binding Structural Molecule Activity Protein Homodimerization Activity Positive Regulation Of Platelet Aggregation Calcium-dependent Protein Binding T-helper 17 Cell Lineage Commitment S100 Protein Binding Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment External Side Of Plasma Membrane Regulation Of Platelet Aggregation T Cell Lineage Commitment Cytokine-mediated Signaling Pathway Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Receptor Complex Ciliary Neurotrophic Factor Binding Growth Factor Binding Acyl Carrier Activity Coated Vesicle Membrane Vasodilation Structural Constituent Of Skin Epidermis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Presynaptic Membrane Organization	Ciliary Neurotrophic Factor Receptor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Leukemia Inhibitory Factor Receptor Activity CRLF-CLCF1 Complex Oncostatin-M Receptor Activity Negative Regulation Of Neuron Apoptotic Process Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cytokine Binding Oncostatin-M-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Cell Population Proliferation Cytokine Activity Interleukin-6 Receptor Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Neuron Apoptotic Process Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Regulation Of Cell Population Proliferation Regulation Of Astrocyte Differentiation Receptor Complex Positive Regulation Of Glial Cell Differentiation Regulation Of Adaptive Immune Response Positive Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Growth Factor Binding Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Activation Positive Regulation Of Immune Response Extracellular Region Regulation Of Leukocyte Proliferation Positive Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Gliogenesis Regulation Of Apoptotic Process Regulation Of Glial Cell Differentiation Regulation Of Programmed Cell Death Extracellular Space Positive Regulation Of Lymphocyte Activation External Side Of Plasma Membrane Interleukin-27 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Lead Ion Binding
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