CNTF and CNTFR

Number of citations of the paper that reports this interaction (PMID 10812968)
25

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CNTF	CNTFR
Gene Name		ciliary neurotrophic factor	ciliary neurotrophic factor receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm CRLF-CLCF1 Complex	Extrinsic Component Of Membrane Anchored Component Of Membrane Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex
	Molecular Function	Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Growth Factor Activity	Ciliary Neurotrophic Factor Receptor Activity Receptor Binding Cytokine Binding
	Biological Process	Signal Transduction Positive Regulation Of Cell Proliferation Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Muscle Organ Morphogenesis Neuron Development Ciliary Neurotrophic Factor-mediated Signaling Pathway	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: APOE CNTFR IL6R IL6ST KRT40 LIFR TRIP6	9 interactors: APPBP2 CLCF1 CNTF CRLF1 HN1L IL6ST KRTAP4-12 LIFR PLSCR1
Entrez ID		1270	1271
HPRD ID		00347	00348
Ensembl ID		ENSG00000242689	ENSG00000122756
Uniprot IDs		P26441	P26992
PDB IDs		1CNT	1UC6
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Cellular Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Organic Substance Positive Regulation Of JAK-STAT Cascade Signal Transduction Positive Regulation Of Osteoblast Differentiation Signaling Cell Communication Regulation Of JAK-STAT Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Interleukin-11-mediated Signaling Pathway Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Ossification Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Response To Stimulus Hepatic Immune Response Positive Regulation Of Neurofibrillary Tangle Assembly Interleukin-27-mediated Signaling Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phospholipid Efflux Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization	Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Response To Cytokine Positive Regulation Of Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Astrocyte Differentiation Cytokine-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Protein Phosphorylation Regulation Of Astrocyte Differentiation Regulation Of Neuron Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Glial Cell Differentiation Regulation Of Neuron Death Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Positive Regulation Of Gliogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Interleukin-11-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Gliogenesis Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Death Interleukin-27-mediated Signaling Pathway
Tagcloud ?		cascades cg ciliary compares converge defines deprived evident extensively feel glia hematopoiesis increasingly jak jak1 neurotrophic ol oligodendrocyte oligodendroglia oligodendroglial pdgf pleiotropic progenitor progenitors responded stat stat1alpha stats trophic	acidic afgf albino bfgf ciliary college dystrophy fgf fgfr1 fibrillary gfap hybridizations igfr inherited injured minimize neurotrophic persisted photoreceptor prompt rcs retina royal slower subretinal surgeons trkb vicinity
Tagcloud (Difference) ?		cascades cg compares converge defines deprived evident extensively feel glia hematopoiesis increasingly jak jak1 ol oligodendrocyte oligodendroglia oligodendroglial pdgf pleiotropic progenitor progenitors responded stat stat1alpha stats trophic	acidic afgf albino bfgf college dystrophy fgf fgfr1 fibrillary gfap hybridizations igfr inherited injured minimize persisted photoreceptor prompt rcs retina royal slower subretinal surgeons trkb vicinity
Tagcloud (Intersection) ?		ciliary neurotrophic