HOMER1 and DNM3

Number of citations of the paper that reports this interaction (PubMedID 9808459)
0

Data Source:
HPRD (in vitro)

		HOMER1	DNM3
Description		homer scaffold protein 1	dynamin 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Z Disc Axon Dendrite Cell Projection Neuron Projection Costamere Dendritic Spine Neuron Spine Apical Part Of Cell Synapse Postsynapse Glutamatergic Synapse Postsynaptic Cytosol	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Postsynaptic Density Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse
	Molecular Function	Protein Binding G Protein-coupled Glutamate Receptor Binding Signaling Adaptor Activity Transmembrane Transporter Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Hydrolase Activity Identical Protein Binding
	Biological Process	Skeletal Muscle Contraction Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Behavioral Response To Cocaine Skeletal Muscle Fiber Development Protein Tetramerization Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Calcium Ion Import Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry	Endocytosis Synapse Assembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Filopodium Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling MHC class II antigen presentation Recycling pathway of L1 Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Blood and toenail selenium levels ( 25343990) Cryptococcosis in HIV infection ( 33269293) Height ( 18193045) Hepcidin/ferritin ratio ( 27846281) Lateral ventricle temporal horn volume ( 31530798) Major depressive disorder ( 20673876) Metabolite levels ( 23823483) Toenail selenium levels ( 25343990)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Diastolic blood pressure ( 28135244 27841878) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 28869591 30598549) Height ( 28552196 20881960 23563607 25282103 25429064 31562340 18391951) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29083408) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Mean platelet volume ( 27863252 32888494 24026423 22139419 19820697) Ovarian cancer ( 30557369) Platelet count ( 33545615 29403010 32888494 22139419 27863252) Platelet distribution width ( 32888494 27863252) QT interval (sulfonylurea treatment interaction) ( 27958378) Red blood cell count ( 32888494) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Uterine fibroids ( 31249589) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		31 interacting genes: ABI1 ABI3 AGAP2 AIMP1 BRME1 C1orf116 DBNL DNM3 EFNB2 FAM9A FAT1 FCHSD2 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 PATJ PIAS2 RAD54L2 RASAL3 RYR1 RYR2 SHANK1 SHANK2 STX12 SYCE2 TANC1 TRPC1 ZMYM5	6 interacting genes: DYNLL1 DYRK1A HOMER1 HSPA13 PCNT SNCA
Entrez ID		9456	26052
HPRD ID		09211	13241
Ensembl ID		ENSG00000152413	ENSG00000197959
Uniprot IDs		Q5U5K4 Q86YM7	H0YBC6 Q9UQ16
PDB IDs			3L43 5A3F
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Glutamate Receptor Signaling Pathway Regulation Of Cytosolic Calcium Ion Concentration Cell Junction Organization Glutamatergic Synapse Dendritic Spine Monoatomic Ion Channel Activity Synapse Synapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Intracellularly Gated Calcium Channel Activity Schaffer Collateral - CA1 Synapse Ligand-gated Ion Channel Signaling Pathway Intracellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Postsynaptic Density Membrane Dendrite Neuron Projection Calcium Ion Homeostasis Postsynaptic Membrane Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Glutamate Receptor Signaling Pathway Cell-cell Signaling Learning Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Ryanodine-sensitive Calcium-release Channel Activity Signaling Calcium-mediated Signaling Cell Communication Calcium Channel Activity Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Associative Learning Synapse Assembly Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Calcium-induced Calcium Release Activity Dendritic Shaft Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Actin-based Cell Projection Regulation Of Sequestering Of Calcium Ion Cell Junction Assembly Glutamate-gated Calcium Ion Channel Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum	Negative Regulation Of Microtubule Polymerization Behavioral Response To Cocaine Regulation Of Microtubule Polymerization Axon Microtubule Regulation Of Amide Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Histone H3T45 Kinase Activity Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Enzyme Inhibitor Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Tetramerization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Calcium Ion Transport Cytoskeleton Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Centrosome Negative Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Intracellular Transport Regulation Of Transport Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity G Protein-coupled Glutamate Receptor Binding Adult Behavior Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Heterochromatin Formation Molecular Adaptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Monoatomic Ion Transport Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly
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