CACNA1D and JPH4

Number of citations of the paper that reports this interaction (PubMedID 31461656)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CACNA1D	JPH4
Description		calcium voltage-gated channel subunit alpha1 D	junctophilin 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Z Disc T-tubule Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Junctional Membrane Complex Dendritic Shaft
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Cytoskeletal Protein Binding High Voltage-gated Calcium Channel Activity Ankyrin Binding Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential	Protein Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Cell Communication Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of Metal Ion Transport Signaling Monoatomic Ion Transmembrane Transport Positive Regulation Of Adenylate Cyclase Activity Nervous System Process Positive Regulation Of Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Calcium Ion Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Regulation Of Cytokine Production Learning Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Synaptic Plasticity Neuromuscular Process Controlling Balance Calcium Ion Transport Into Cytosol Regulation Of Store-operated Calcium Entry
Pathways		Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Sensory processing of sound by inner hair cells of the cochlea
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Age at first sexual intercourse ( 34211149 27089180) Appendicular lean mass ( 33097823) Axial length ( 24144296) Body mass index ( 25673413) Body size at age 10 ( 32376654) Diastolic blood pressure ( 25249183 30578418 29403010 30487518) Electrocardiographic traits ( 25055868) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hypertension ( 25249183 30487518) Insomnia ( 29520036) Insulin resistance/response ( 21901158) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) PR interval ( 32439900) Pulse pressure ( 30487518) Pursuit maintenance gain ( 29064472) Refractive error ( 23396134 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30578418 30487518 25249183 29403010) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)
Interacting Genes		7 interacting genes: CALB1 FGFR2 JPH3 JPH4 KCNN4 RYR2 STX1A	6 interacting genes: BCL2L13 CACNA1D KCNN4 RYR2 UBQLN1 UBQLN2
Entrez ID		776	84502
HPRD ID		00247	17170
Ensembl ID		ENSG00000157388	ENSG00000092051
Uniprot IDs		A0A1B0GUN6 Q01668 Q59GD8	Q96JJ6
PDB IDs		3LV3 7UHF 7UHG 8E59 8E5A 8E5B
Enriched GO Terms of Interacting Partners?		Junctional Sarcoplasmic Reticulum Membrane Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Junctional Membrane Complex Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Calcium Ion Transmembrane Import Into Cytosol Regulation Of Metal Ion Transport Regulation Of Striated Muscle Contraction Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Sequestering Of Calcium Ion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Endoplasmic Reticulum Calcium-mediated Signaling Regulation Of Muscle Contraction Regulation Of System Process Metal Ion Transport Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Heart Contraction Regulation Of Synaptic Plasticity Regulation Of Biological Quality System Process Inorganic Ion Transmembrane Transport Regulation Of Muscle System Process Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Transport Learning Or Memory Ventricular Cardiac Muscle Tissue Morphogenesis Neuromuscular Process Controlling Balance Cognition Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Tissue Morphogenesis Monoatomic Ion Transport Neuron Projection Metanephric Connecting Tubule Development Kidney Epithelium Development Calcium Ion Binding Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Signaling	Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Transport Calcium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagy Regulation Of Potassium Ion Transmembrane Transport Calcium Channel Activity Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Intermediate Conductance Calcium-activated Potassium Channel Activity Autophagosome Negative Regulation Of Store-operated Calcium Channel Activity Calcium Ion Transmembrane Import Into Cytosol Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Regulation Of Heart Rate Autophagosome Organization Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Suramin Binding Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Z Disc Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Stabilization Of Membrane Potential Ryanodine-sensitive Calcium-release Channel Activity Type B Pancreatic Cell Apoptotic Process Regulation Of AV Node Cell Action Potential Left Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Inorganic Ion Transmembrane Transport Macroautophagy Monoatomic Ion Channel Activity Small Conductance Calcium-activated Potassium Channel Activity
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