CACNA1D and CALB1

Number of citations of the paper that reports this interaction (PubMedID 17257825)
31

Data Source:
BioGRID (pull down)

		CACNA1D	CALB1
Description		calcium voltage-gated channel subunit alpha1 D	calbindin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Z Disc T-tubule Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex	Nucleus Cytoplasm Cytosol Axon Dendrite Stereocilium Cuticular Plate Neuron Projection Neuronal Cell Body Terminal Bouton Calyx Of Held Synapse Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Cytoskeletal Protein Binding High Voltage-gated Calcium Channel Activity Ankyrin Binding Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential	Vitamin D Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Metal Ion Binding Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Calcium Ion Binding Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Cell Communication Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of Metal Ion Transport Signaling Monoatomic Ion Transmembrane Transport Positive Regulation Of Adenylate Cyclase Activity Nervous System Process Positive Regulation Of Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Calcium Ion Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Learning Or Memory Short-term Memory Long-term Memory Locomotory Behavior Retina Layer Formation Response To Auditory Stimulus Metanephric Part Of Ureteric Bud Development Regulation Of Synaptic Plasticity Calcium Ion Homeostasis Retina Development In Camera-type Eye Metanephric Collecting Duct Development Metanephric Distal Convoluted Tubule Development Metanephric Connecting Tubule Development Cochlea Development Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways		Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Sensory processing of sound by inner hair cells of the cochlea	Amyloid fiber formation
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Age at first sexual intercourse ( 34211149 27089180) Appendicular lean mass ( 33097823) Axial length ( 24144296) Body mass index ( 25673413) Body size at age 10 ( 32376654) Diastolic blood pressure ( 25249183 30578418 29403010 30487518) Electrocardiographic traits ( 25055868) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hypertension ( 25249183 30487518) Insomnia ( 29520036) Insulin resistance/response ( 21901158) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) PR interval ( 32439900) Pulse pressure ( 30487518) Pursuit maintenance gain ( 29064472) Refractive error ( 23396134 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30578418 30487518 25249183 29403010) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)	Chronotype ( 27494321 30696823) Morning vs. evening chronotype ( 27494321)
Interacting Genes		7 interacting genes: CALB1 FGFR2 JPH3 JPH4 KCNN4 RYR2 STX1A	6 interacting genes: CACNA1D IKBKG IMPA1 RANBP9 TRPV5 TRPV6
Entrez ID		776	793
HPRD ID		00247	00229
Ensembl ID		ENSG00000157388	ENSG00000104327
Uniprot IDs		A0A1B0GUN6 Q01668 Q59GD8	P05937
PDB IDs		3LV3 7UHF 7UHG 8E59 8E5A 8E5B	6FIE
Enriched GO Terms of Interacting Partners?		Junctional Sarcoplasmic Reticulum Membrane Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Junctional Membrane Complex Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Calcium Ion Transmembrane Import Into Cytosol Regulation Of Metal Ion Transport Regulation Of Striated Muscle Contraction Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Sequestering Of Calcium Ion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Endoplasmic Reticulum Calcium-mediated Signaling Regulation Of Muscle Contraction Regulation Of System Process Metal Ion Transport Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Heart Contraction Regulation Of Synaptic Plasticity Regulation Of Biological Quality System Process Inorganic Ion Transmembrane Transport Regulation Of Muscle System Process Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Transport Learning Or Memory Ventricular Cardiac Muscle Tissue Morphogenesis Neuromuscular Process Controlling Balance Cognition Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Tissue Morphogenesis Monoatomic Ion Transport Neuron Projection Metanephric Connecting Tubule Development Kidney Epithelium Development Calcium Ion Binding Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Signaling	Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Inorganic Cation Import Across Plasma Membrane Import Across Plasma Membrane Monoatomic Ion Channel Activity Calcium Ion Transmembrane Transport Calcium Channel Complex Calcium Ion Transport Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Glycerol-2-phosphatase Activity Lithium Ion Binding Inositol Monophosphate 4-phosphatase Activity Inositol Monophosphate Phosphatase Activity Inositol Monophosphate 1-phosphatase Activity Glucose-1-phosphatase Activity Inositol Monophosphate 3-phosphatase Activity Fructose-1-phosphatase Activity Ubiquitin Ligase Complex Parathyroid Hormone Secretion Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Inositol Biosynthetic Process Glucose-6-phosphatase Activity Linear Polyubiquitin Binding Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Membrane Depolarization During SA Node Cell Action Potential Calmodulin Binding Metal Ion Binding Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Inositol Metabolic Process IkappaB Kinase Complex Calcium Ion Homeostasis Monoatomic Ion Transport L-type Voltage-gated Calcium Channel Complex Transferrin Receptor Binding Anoikis High Voltage-gated Calcium Channel Activity Calcium Ion Transport Into Cytosol Transmembrane Transport Alpha-actinin Binding Membrane Depolarization During Cardiac Muscle Cell Action Potential Ankyrin Binding
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