CACNA1D and KCNN4

Number of citations of the paper that reports this interaction (PubMedID 31461656)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CACNA1D	KCNN4
Description		calcium voltage-gated channel subunit alpha1 D	potassium calcium-activated channel subfamily N member 4
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Z Disc T-tubule Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Vesicle Ruffle Membrane Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Cytoskeletal Protein Binding High Voltage-gated Calcium Channel Activity Ankyrin Binding Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential	Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Phosphatase Binding Intermediate Conductance Calcium-activated Potassium Channel Activity Protein Homodimerization Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Cell Communication Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of Metal Ion Transport Signaling Monoatomic Ion Transmembrane Transport Positive Regulation Of Adenylate Cyclase Activity Nervous System Process Positive Regulation Of Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Calcium Ion Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Immune System Process Monoatomic Ion Transport Potassium Ion Transport Calcium Ion Transport Cell Volume Homeostasis Defense Response Stabilization Of Membrane Potential Monoatomic Ion Transmembrane Transport Macropinocytosis Phospholipid Translocation Saliva Secretion Positive Regulation Of Protein Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Transport Protein Homotetramerization Establishment Of Localization In Cell Regulation Of Biological Quality Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Sensory processing of sound by inner hair cells of the cochlea	Ca2+ activated K+ channels
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil	Clotrimazole Quinine Procaine Ritodrine Nitrendipine Miconazole Halothane Colforsin Trimebutine
Diseases
GWAS		Age at first sexual intercourse ( 34211149 27089180) Appendicular lean mass ( 33097823) Axial length ( 24144296) Body mass index ( 25673413) Body size at age 10 ( 32376654) Diastolic blood pressure ( 25249183 30578418 29403010 30487518) Electrocardiographic traits ( 25055868) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hypertension ( 25249183 30487518) Insomnia ( 29520036) Insulin resistance/response ( 21901158) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) PR interval ( 32439900) Pulse pressure ( 30487518) Pursuit maintenance gain ( 29064472) Refractive error ( 23396134 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30578418 30487518 25249183 29403010) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)	Breast cancer ( 23535729) Granulocyte percentage of myeloid white cells ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CALB1 FGFR2 JPH3 JPH4 KCNN4 RYR2 STX1A	13 interacting genes: BIK CACNA1D CALM1 CNIH3 FXYD3 GPR152 JPH3 JPH4 PMP22 PRKAG1 RYR2 SLC30A2 STX1B
Entrez ID		776	3783
HPRD ID		00247	04130
Ensembl ID		ENSG00000157388	ENSG00000104783
Uniprot IDs		A0A1B0GUN6 Q01668 Q59GD8	O15554
PDB IDs		3LV3 7UHF 7UHG 8E59 8E5A 8E5B	6CNM 6CNN 6CNO 6D42
Enriched GO Terms of Interacting Partners?		Junctional Sarcoplasmic Reticulum Membrane Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Junctional Membrane Complex Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Calcium Ion Transmembrane Import Into Cytosol Regulation Of Metal Ion Transport Regulation Of Striated Muscle Contraction Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Sequestering Of Calcium Ion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Endoplasmic Reticulum Calcium-mediated Signaling Regulation Of Muscle Contraction Regulation Of System Process Metal Ion Transport Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Heart Contraction Regulation Of Synaptic Plasticity Regulation Of Biological Quality System Process Inorganic Ion Transmembrane Transport Regulation Of Muscle System Process Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Transport Learning Or Memory Ventricular Cardiac Muscle Tissue Morphogenesis Neuromuscular Process Controlling Balance Cognition Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Tissue Morphogenesis Monoatomic Ion Transport Neuron Projection Metanephric Connecting Tubule Development Kidney Epithelium Development Calcium Ion Binding Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Signaling	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Metal Ion Transport Calcium Ion Transport Into Cytosol Regulation Of Heart Contraction Regulation Of Monoatomic Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Regulation Of Striated Muscle Contraction Regulation Of Blood Circulation Regulation Of System Process Metal Ion Transport Regulation Of Sequestering Of Calcium Ion Regulation Of Calcium Ion Transmembrane Transport Regulation Of Transport Inorganic Ion Transmembrane Transport Calcium-mediated Signaling Membrane Regulation Of Muscle Contraction Junctional Membrane Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Membrane Potential Plasma Membrane Calcium Ion Transport Monoatomic Ion Transport Regulation Of Muscle System Process Detection Of Calcium Ion Inorganic Cation Transmembrane Transport Regulation Of Heart Rate Monoatomic Cation Transmembrane Transport Transmembrane Transport Smooth Endoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cardiac Muscle Cell Action Potential Protein Kinase Binding Cardiac Muscle Cell Action Potential Involved In Contraction Modulation Of Chemical Synaptic Transmission Cardiac Muscle Cell Action Potential Regulation Of Synaptic Plasticity Dendritic Shaft
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