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RPS6 and UPF2
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
BioGRID
(two hybrid)
RPS6
UPF2
Description
ribosomal protein S6
UPF2 regulator of nonsense mediated mRNA decay
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Ribosome
Small Ribosomal Subunit
Membrane
Cytosolic Ribosome
Cytosolic Small Ribosomal Subunit
Dendrite
Small-subunit Processome
Cytoplasmic Ribonucleoprotein Granule
Cell Body
Presynapse
GABA-ergic Synapse
Ribonucleoprotein Complex
Nucleus
Cytoplasm
Cytosol
Exon-exon Junction Complex
Cytoplasmic Ribonucleoprotein Granule
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Binding
MRNA Binding
Structural Constituent Of Ribosome
Protein Binding
Protein Kinase Binding
RNA Binding
Protein Binding
Telomeric DNA Binding
Biological Process
Ribosomal Small Subunit Assembly
Cytoplasmic Translation
RRNA Processing
Translation
Positive Regulation Of Cell Population Proliferation
TOR Signaling
Response To Insulin
Ribosomal Small Subunit Biogenesis
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Cellular Response To Ethanol
Negative Regulation Of Bicellular Tight Junction Assembly
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Liver Development
MRNA Export From Nucleus
Animal Organ Regeneration
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
mTORC1-mediated signalling
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Protein hydroxylation
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nuclear events stimulated by ALK signaling in cancer
SARS-CoV-1 modulates host translation machinery
SARS-CoV-2 modulates host translation machinery
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Artenimol
Diseases
GWAS
Total cholesterol levels (
29083408
)
Diverticular disease (
30177863
)
Interacting Genes
20 interacting genes:
ATF4
DUX4
EIF4ENIF1
ERCC6
FNDC3B
FRS2
MTOR
MYOM2
NDRG1
OLFM2
PAK2
PLA2G12A
PRKACB
PRKCSH
PTEN
RPS6KB1
RPS6KB2
STAU1
UPF2
USP7
76 interacting genes:
ABCF2
AGPAT1
AKTIP
ART4
ATP1B3
BLM
CALR
CENPU
CIZ1
COMTD1
CYBA
DCP1B
DCP2
DPF2
E4F1
EIF1
EIF4A1
EIF4G1
ENO1
EXOSC1
EXOSC10
EXOSC4
EXOSC6
EXOSC8
GADD45GIP1
HBZ
HMGA1
HS3ST3A1
HSF2BP
ITGB1
KRT18
LDHA
LSM1
MAP1A
MAP1LC3B
MIF
MRPL40
MTERF3
MTREX
MYB
NDUFA7
NOB1
NOMO1
NOP53
PHB2
PITX1
PUF60
RNPS1
RPL13
RPL5
RPL8
RPS15
RPS25
RPS6
RPS7
RRP7A
RSRC2
SERBP1
SERF2
SMG1
SUMO3
TK1
TNNI2
TOP3B
TUBB2A
TYMS
UPF1
UPF3B
WNK1
XRN1
XRN2
ZBTB48
ZFP36
ZGPAT
ZNF408
ZNF44
Entrez ID
6194
26019
HPRD ID
01592
10405
Ensembl ID
ENSG00000137154
ENSG00000151461
Uniprot IDs
A2A3R6
P62753
Q9HAU5
PDB IDs
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6F4P
6F4Q
6FEC
6G18
6G4S
6G4W
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBW
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOK
6ZON
6ZP4
6ZUO
6ZV6
6ZVH
6ZVJ
6ZXD
6ZXE
6ZXF
6ZXG
6ZXH
7A09
7K5I
7MQ8
7MQ9
7MQA
7QP6
7QP7
7QVP
7R4X
7TQL
7WTS
7WTT
7WTU
7WTV
7WTW
7WTX
7WTZ
7WU0
7XNX
7XNY
7ZJW
7ZJX
8G5Y
8G5Z
8G60
8G61
8G6J
8GLP
8IFD
8IFE
8JDJ
8JDK
8JDL
8JDM
8K2C
8OZ0
8PJ1
8PJ2
8PJ3
8PJ4
8PJ5
8PJ6
8PPK
8PPL
8QOI
8T4S
8UKB
8XP2
8XP3
8XSX
8XSY
8XSZ
8XXL
8XXM
8XXN
8Y0W
8Y0X
8YOO
8YOP
8ZDB
8ZDC
8ZDD
9BKD
9BLN
9C3H
9G8M
9G8O
1UW4
2WJV
4CEK
4CEM
7NWU
7QG6
Enriched GO Terms of Interacting Partners
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TORC1 Signaling
TOR Signaling
Cellular Response To Nutrient Levels
Intracellular Signal Transduction
Negative Regulation Of TORC1 Signaling
Regulation Of Protein Metabolic Process
Negative Regulation Of TOR Signaling
Regulation Of TORC1 Signaling
Regulation Of Translational Initiation
Cytoplasm
Positive Regulation Of Transcription By RNA Polymerase I
PML Body
Negative Regulation Of TORC2 Signaling
Response To Nutrient Levels
Regulation Of Transcription By RNA Polymerase I
Positive Regulation Of Translational Initiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Regulation Of TOR Signaling
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Protein Metabolic Process
Protein Serine Kinase Activity
Negative Regulation Of Cell Size
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Protein Serine/threonine Kinase Activity
Regulation Of Insulin Receptor Signaling Pathway
Transcription-coupled Nucleotide-excision Repair
Cellular Response To Leucine Starvation
Regulation Of Translation
Regulation Of Cellular Response To Insulin Stimulus
Regulation Of TORC2 Signaling
Cytoplasmic Ribonucleoprotein Granule
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
TORC2 Signaling
Vascular Endothelial Cell Response To Fluid Shear Stress
Myelin Maintenance
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Tyrosine Kinase Activator Activity
Signal Transduction
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase III
Autophagosome Assembly
Cellular Response To Laminar Fluid Shear Stress
Cellular Response To Stress
Autophagosome Organization
Protein Kinase Activity
Negative Regulation Of Autophagy
Response To Laminar Fluid Shear Stress
Positive Regulation Of Catabolic Process
Cytoplasmic Translation
RNA Binding
Nuclear-transcribed MRNA Catabolic Process
RNA Catabolic Process
MRNA Catabolic Process
Nucleobase-containing Compound Catabolic Process
RRNA Metabolic Process
RRNA Processing
Nucleic Acid Metabolic Process
Exosome (RNase Complex)
Nucleus
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
RNA Metabolic Process
Histone MRNA Catabolic Process
Nuclear Exosome (RNase Complex)
Negative Regulation Of Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nucleolar Exosome (RNase Complex)
Negative Regulation Of Macromolecule Biosynthetic Process
Nuclear MRNA Surveillance
Ribosome
Histone MRNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Cytoplasmic Exosome (RNase Complex)
RNA Exonuclease Activity
Regulation Of Gene Expression
Ribonucleoprotein Complex Biogenesis
Regulation Of Macromolecule Biosynthetic Process
MRNA Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
RNA Processing
Ribosomal Small Subunit Biogenesis
Translation
Regulation Of Macromolecule Metabolic Process
Ribonucleoprotein Complex
Nucleolus
Nucleic Acid Binding
Cytosolic Ribosome
Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
5'-3' RNA Exonuclease Activity
Regulation Of Metabolic Process
Nuclear RNA Surveillance
RRNA Catabolic Process
RNA Surveillance
DNA Metabolic Process
Cytosol
Cytoplasmic Translation
Negative Regulation Of Protein Metabolic Process
Macromolecule Catabolic Process
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