RPS6 and RPS6KB1

Number of citations of the paper that reports this interaction (PMID 16810323)
33

Data Source:
HPRD (in vitro)

		RPS6	RPS6KB1
Gene Name		ribosomal protein S6	ribosomal protein S6 kinase, 70kDa, polypeptide 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Polysome Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Cell Body Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Cell Junction Neuron Projection Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding Poly(A) RNA Binding	Protein Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Peptide Binding
	Biological Process	Ribosomal Small Subunit Assembly G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Placenta Development T Cell Proliferation Involved In Immune Response RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Activation-induced Cell Death Of T Cells Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Gastrulation Insulin Receptor Signaling Pathway Gene Expression Viral Process Viral Life Cycle Viral Transcription Oogenesis Stage TOR Signaling T Cell Differentiation In Thymus Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Erythrocyte Development	G1/S Transition Of Mitotic Cell Cycle Skeletal Muscle Contraction Protein Phosphorylation Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Insulin Receptor Signaling Pathway Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration TOR Signaling Response To Lipopolysaccharide Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Response To Glucocorticoid Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling Peptide chain elongation IGF1R signaling cascade Influenza Life Cycle Formation of the ternary complex, and subsequently, the 43S complex IRS-related events triggered by IGF1R Influenza Viral RNA Transcription and Replication Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Insulin receptor signalling cascade Translation SRP-dependent cotranslational protein targeting to membrane S6K1 signalling Eukaryotic Translation Termination IRS-related events Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits PKB-mediated events Eukaryotic Translation Elongation PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1 signalling S6K1-mediated signalling IRS-related events mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling S6K1 signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PKB-mediated events PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661)
Protein-Protein Interactions		12 interactors: ATF4 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH RPS4X RPS6KB1 RPS6KB2 STAU1 UPF2	54 interactors: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DPPA4 EEF2K EIF4B EIF4EBP1 EP300 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MLST8 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RICTOR RPS6 RPTOR SRC STK11 SYK TERT TRAF4 URI1 XPO1
Entrez ID		6194	6198
HPRD ID		01592	10202
Ensembl ID		ENSG00000137154	ENSG00000108443
Uniprot IDs		A2A3R5 A2A3R6 P62753	B2R779 B4DLT4 B4DTG1 F6UYM1 P23443 Q7Z721
PDB IDs		3J3A	3A60 3A61 3A62 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Translational Initiation Protein Kinase B Signaling Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Translation Response To Glucagon Regulation Of Protein Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Innate Immune Response Response To Stress Response To Clozapine Regulation Of Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Growth Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Positive Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Cellular Protein Metabolic Process Glucose Metabolic Process Positive Regulation Of Transferase Activity Skeletal Muscle Atrophy Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Nuclear-transcribed MRNA Catabolic Process RNA Localization Liver Development Carbohydrate Biosynthetic Process Cellular Response To Growth Factor Stimulus Immune System Process MRNA Catabolic Process Striated Muscle Atrophy Response To Leucine Immune Response Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Phosphorylation Defense Response Muscle Atrophy	Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Peptide Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Signal Transduction Regulation Of Signaling Innate Immune Response Intracellular Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Communication Immune Response Positive Regulation Of Protein Modification Process Regulation Of Kinase Activity Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process T Cell Costimulation Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		acidified autophagy basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic mtorc1 nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1	70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk
Tagcloud (Difference) ?		acidified basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic nelfinavir normalised signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1	70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic crosstalk h160f impairs interested mtorc2 nonsenescent polypeptide prkaa replicative rictor senescent ureahydrolase wk
Tagcloud (Intersection) ?		autophagy mtorc1 s6k1