RPS6 and PAK2

Number of citations of the paper that reports this interaction (PMID 1985906)
0

Data Source:
HPRD (in vitro)

		RPS6	PAK2
Gene Name		ribosomal protein S6	p21 protein (Cdc42/Rac)-activated kinase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Polysome Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Cell Body Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding
	Biological Process	Ribosomal Small Subunit Assembly G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Placenta Development T Cell Proliferation Involved In Immune Response RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Activation-induced Cell Death Of T Cells Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Gastrulation Insulin Receptor Signaling Pathway Gene Expression Viral Process Viral Life Cycle Viral Transcription Oogenesis Stage TOR Signaling T Cell Differentiation In Thymus Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Erythrocyte Development	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling Peptide chain elongation IGF1R signaling cascade Influenza Life Cycle Formation of the ternary complex, and subsequently, the 43S complex IRS-related events triggered by IGF1R Influenza Viral RNA Transcription and Replication Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Insulin receptor signalling cascade Translation SRP-dependent cotranslational protein targeting to membrane S6K1 signalling Eukaryotic Translation Termination IRS-related events Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits PKB-mediated events Eukaryotic Translation Elongation PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System
Drugs
Diseases
GWAS			Total ventricular volume ( 21116278)
Protein-Protein Interactions		12 interactors: ATF4 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH RPS4X RPS6KB1 RPS6KB2 STAU1 UPF2	51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		6194	5062
HPRD ID		01592	05428
Ensembl ID		ENSG00000137154	ENSG00000180370
Uniprot IDs		A2A3R5 A2A3R6 P62753	A8K5M4 Q13177
PDB IDs		3J3A	3PCS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Translational Initiation Protein Kinase B Signaling Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Translation Response To Glucagon Regulation Of Protein Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Innate Immune Response Response To Stress Response To Clozapine Regulation Of Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Growth Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Positive Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Cellular Protein Metabolic Process Glucose Metabolic Process Positive Regulation Of Transferase Activity Skeletal Muscle Atrophy Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Nuclear-transcribed MRNA Catabolic Process RNA Localization Liver Development Carbohydrate Biosynthetic Process Cellular Response To Growth Factor Stimulus Immune System Process MRNA Catabolic Process Striated Muscle Atrophy Response To Leucine Immune Response Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Phosphorylation Defense Response Muscle Atrophy	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death
Tagcloud ?		acidified autophagy basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic mtorc1 nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		acidified autophagy basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic mtorc1 nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Intersection) ?