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RPS6 and PAK2
Number of citations of the paper that reports this interaction (PubMedID
1985906
)
0
Data Source:
HPRD
(in vitro)
RPS6
PAK2
Description
ribosomal protein S6
p21 (RAC1) activated kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Ribosome
Small Ribosomal Subunit
Membrane
Cytosolic Ribosome
Cytosolic Small Ribosomal Subunit
Dendrite
Small-subunit Processome
Cytoplasmic Ribonucleoprotein Granule
Cell Body
Presynapse
GABA-ergic Synapse
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Postsynaptic Density
Membrane
Nuclear Speck
Secretory Granule
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Molecular Function
RNA Binding
MRNA Binding
Structural Constituent Of Ribosome
Protein Binding
Protein Kinase Binding
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Biological Process
Ribosomal Small Subunit Assembly
Cytoplasmic Translation
RRNA Processing
Translation
Positive Regulation Of Cell Population Proliferation
TOR Signaling
Response To Insulin
Ribosomal Small Subunit Biogenesis
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Cellular Response To Ethanol
Negative Regulation Of Bicellular Tight Junction Assembly
Stimulatory C-type Lectin Receptor Signaling Pathway
Cardiac Muscle Hypertrophy
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Starvation
Cell Migration
Adherens Junction Assembly
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Protein Maturation
Dendritic Spine Development
Bicellular Tight Junction Assembly
Cellular Response To Transforming Growth Factor Beta Stimulus
Execution Phase Of Apoptosis
Regulation Of Actin Filament Organization
Protein Localization To Cell-cell Junction
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
mTORC1-mediated signalling
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Protein hydroxylation
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nuclear events stimulated by ALK signaling in cancer
SARS-CoV-1 modulates host translation machinery
SARS-CoV-2 modulates host translation machinery
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Drugs
Artenimol
Fostamatinib
Diseases
GWAS
Total cholesterol levels (
29083408
)
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil count (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
27863252
32888494
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
27863252
32888494
)
Neutrophil count (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
27863252
32888494
)
Interacting Genes
20 interacting genes:
ATF4
DUX4
EIF4ENIF1
ERCC6
FNDC3B
FRS2
MTOR
MYOM2
NDRG1
OLFM2
PAK2
PLA2G12A
PRKACB
PRKCSH
PTEN
RPS6KB1
RPS6KB2
STAU1
UPF2
USP7
54 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
CEBPA
DOCK2
DSCR9
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
OGT
PACSIN3
PPM1A
RAC1
RAF1
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
6194
5062
HPRD ID
01592
05428
Ensembl ID
ENSG00000137154
ENSG00000180370
Uniprot IDs
A2A3R6
P62753
A8K5M4
Q13177
PDB IDs
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6F4P
6F4Q
6FEC
6G18
6G4S
6G4W
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBW
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOK
6ZON
6ZP4
6ZUO
6ZV6
6ZVH
6ZVJ
6ZXD
6ZXE
6ZXF
6ZXG
6ZXH
7A09
7K5I
7MQ8
7MQ9
7MQA
7QP6
7QP7
7QVP
7R4X
7TQL
7WTS
7WTT
7WTU
7WTV
7WTW
7WTX
7WTZ
7WU0
7XNX
7XNY
7ZJW
7ZJX
8G5Y
8G5Z
8G60
8G61
8G6J
8GLP
8IFD
8IFE
8JDJ
8JDK
8JDL
8JDM
8K2C
8OZ0
8PJ1
8PJ2
8PJ3
8PJ4
8PJ5
8PJ6
8PPK
8PPL
8QOI
8T4S
8UKB
8XP2
8XP3
8XSX
8XSY
8XSZ
8XXL
8XXM
8XXN
8Y0W
8Y0X
8YOO
8YOP
8ZDB
8ZDC
8ZDD
9BKD
9BLN
9C3H
9G8M
9G8O
3PCS
Enriched GO Terms of Interacting Partners
?
TORC1 Signaling
TOR Signaling
Cellular Response To Nutrient Levels
Intracellular Signal Transduction
Negative Regulation Of TORC1 Signaling
Regulation Of Protein Metabolic Process
Negative Regulation Of TOR Signaling
Regulation Of TORC1 Signaling
Regulation Of Translational Initiation
Cytoplasm
Positive Regulation Of Transcription By RNA Polymerase I
PML Body
Negative Regulation Of TORC2 Signaling
Response To Nutrient Levels
Regulation Of Transcription By RNA Polymerase I
Positive Regulation Of Translational Initiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Regulation Of TOR Signaling
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Protein Metabolic Process
Protein Serine Kinase Activity
Negative Regulation Of Cell Size
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Protein Serine/threonine Kinase Activity
Regulation Of Insulin Receptor Signaling Pathway
Transcription-coupled Nucleotide-excision Repair
Cellular Response To Leucine Starvation
Regulation Of Translation
Regulation Of Cellular Response To Insulin Stimulus
Regulation Of TORC2 Signaling
Cytoplasmic Ribonucleoprotein Granule
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
TORC2 Signaling
Vascular Endothelial Cell Response To Fluid Shear Stress
Myelin Maintenance
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Tyrosine Kinase Activator Activity
Signal Transduction
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase III
Autophagosome Assembly
Cellular Response To Laminar Fluid Shear Stress
Cellular Response To Stress
Autophagosome Organization
Protein Kinase Activity
Negative Regulation Of Autophagy
Response To Laminar Fluid Shear Stress
Positive Regulation Of Catabolic Process
Cytoplasmic Translation
Regulation Of Cellular Component Organization
Cytosol
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Signal Transduction
Regulation Of Vesicle-mediated Transport
Cytoskeleton Organization
Positive Regulation Of Cellular Component Organization
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Cytoplasm
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Enzyme-linked Receptor Protein Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of MAPK Cascade
Focal Adhesion
Protein Phosphorylation
Ephrin Receptor Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Organelle Organization
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Phosphorylation
Positive Regulation Of Cytoskeleton Organization
Signal Transduction
Anchoring Junction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Organelle Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Immune Response-activating Signaling Pathway
Actin Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Endocytosis
Regulation Of Cell Activation
Regulation Of Transport
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Supramolecular Fiber Organization
Regulation Of Endocytosis
Regulation Of T Cell Activation
Ephrin Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Supramolecular Fiber Organization
Actin Filament-based Process
Protein Kinase Activity
Lamellipodium
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Tagcloud (Difference)
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Tagcloud (Intersection)
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