RPLP2 and ADRBK1

Number of citations of the paper that reports this interaction (PMID 14729942)
24

Data Source:
HPRD (in vivo, in vitro)

		RPLP2	ADRBK1
Gene Name		ribosomal protein, large, P2	adrenergic, beta, receptor kinase 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Primary Cilium
	Molecular Function	RNA Binding Structural Constituent Of Ribosome	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Receptor Internalization Positive Regulation Of Catecholamine Secretion Termination Of G-protein Coupled Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Striated Muscle Contraction Neurotrophin TRK Receptor Signaling Pathway Cardiac Muscle Contraction
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	G alpha (q) signalling events Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Hedgehog 'on' state Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Calmodulin induced events Downstream signal transduction PLC-gamma1 signalling Signaling by Hedgehog Signaling by EGFR in Cancer Activation of SMO
Drugs			Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ADRBK1 MAPK8 RPLP1 YWHAQ	47 interactors: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB1 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2
Entrez ID		6181	156
HPRD ID		01612	00182
Ensembl ID			ENSG00000173020
Uniprot IDs		P05387	P25098
PDB IDs		1S4J 2JDL 2LBF 2W1O 3J3B 4BEH	1BAK 3CIK 3KRW 3KRX 3V5W
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Transport Peptidyl-serine Phosphorylation Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Cellular Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport JUN Phosphorylation Positive Regulation Of Deacetylase Activity Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Striated Muscle Contraction Apoptotic Signaling Pathway Regulation Of The Force Of Heart Contraction By Chemical Signal Tachykinin Receptor Signaling Pathway Positive Regulation Of Organelle Organization Positive Regulation Of Catecholamine Secretion Protein Targeting Regulation Of Intracellular Transport Cellular Response To Nitric Oxide G-protein Coupled Acetylcholine Receptor Signaling Pathway Response To Nitric Oxide Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of Muscle Contraction Positive Regulation Of Programmed Cell Death Response To Growth Factor Cellular Response To Reactive Nitrogen Species Negative Regulation Of Heart Contraction Positive Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of The Force Of Heart Contraction Regulation Of Signal Transduction Regulation Of Histone Deacetylation Substantia Nigra Development Regulation Of Protein Localization Innate Immune Response Receptor Internalization Membrane Organization Programmed Necrotic Cell Death Necrotic Cell Death	Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Communication Signaling Platelet Activation Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To External Stimulus Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Metabolic Process Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Cell Activation Regulation Of Body Fluid Levels Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Wound Healing Cellular Calcium Ion Homeostasis Regulation Of Metabolic Process Calcium Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase Activity Response To Wounding
Tagcloud ?		18s actbeta assume atp5b august beta2m canx cited contrasting cyc1 february gapdh gus healing housekeeping july normalization normalizing pig qpcr sdha stably studying tbp ubc unwounded wound wounded ywhaz	adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites
Tagcloud (Difference) ?		18s actbeta assume atp5b august beta2m canx cited contrasting cyc1 february gapdh gus healing housekeeping july normalization normalizing pig qpcr sdha stably studying tbp ubc unwounded wound wounded ywhaz	adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites
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