IFRD1 and RIT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		IFRD1	RIT1
Gene Name		interferon-related developmental regulator 1	Ras-like without CAAX 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Plasma Membrane
	Molecular Function		Protein Binding Calmodulin Binding GTP Binding
	Biological Process	Multicellular Organismal Development Myoblast Fate Determination Adult Somatic Muscle Development	Signal Transduction Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway
Pathways			Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Mortality among heart failure patients ( 20400778)	Conduct disorder (interaction) ( 18846501) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		6 interactors: CSNK2A1 DYT10 HDAC2 HDAC4 MYOD1 RIT1	14 interactors: AP2A1 CUL3 IFRD1 KLHL12 LRIF1 MLLT4 PTN RALGDS RGL1 RLF SMAD2 SMAD3 SMURF1 SRPK2
Entrez ID		3475	6016
HPRD ID		04612	10195
Ensembl ID			ENSG00000143622
Uniprot IDs		A4D0U1 O00458	Q92963
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Striated Muscle Cell Differentiation Regulation Of Striated Muscle Tissue Development Regulation Of Muscle Cell Differentiation Cell Development Regulation Of Skeletal Muscle Fiber Development Histone H4 Deacetylation Regulation Of Cell Development Transcription, DNA-templated RNA Biosynthetic Process Histone H3 Deacetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Histone Modification Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Histone Deacetylation Regulation Of Myotube Differentiation Protein Deacetylation Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Regulation Of Cell Proliferation Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Modification Regulation Of Growth Regulation Of Transcription From RNA Polymerase II Promoter System Development Odontogenesis Of Dentin-containing Tooth Regulation Of Transcription, DNA-templated Olfactory Bulb Axon Guidance Negative Regulation Of Cell Proliferation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Odontogenesis Epidermal Cell Differentiation Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Neuron Projection Development	Signal Transduction Signaling Cell Communication Primary MiRNA Processing Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Paraxial Mesoderm Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Nodal Signaling Pathway Regulation Of Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development COPII Vesicle Coating Anatomical Structure Development Transforming Growth Factor Beta Receptor Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA COPII-coated Vesicle Budding Pericardium Development Regulation Of Cell Proliferation Response To Stimulus Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Vesicle Targeting, To, From Or Within Golgi Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Gastrulation Developmental Process In Utero Embryonic Development Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Metabolic Process Posttranscriptional Gene Silencing Protein Monoubiquitination Vesicle Targeting Localization Within Membrane
Tagcloud ?		adjust affymetrix agreement allelic ancestry autonomic camk4 chrm2 cohorts comt cooperative displaying genotyping grk5 htr2a informative nociceptive nr3c1 oppera orofacial pain panel perspective putatively replicated representing stratification temporomandibular tmd	aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide
Tagcloud (Difference) ?		adjust affymetrix agreement allelic ancestry autonomic camk4 chrm2 cohorts comt cooperative displaying genotyping grk5 htr2a informative nociceptive nr3c1 oppera orofacial pain panel perspective putatively replicated representing stratification temporomandibular tmd	aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide
Tagcloud (Intersection) ?