IFRD1 and KLHL41

Number of citations of the paper that reports this interaction (PubMedID 30986853)
58

Data Source:
BioGRID (two hybrid)

		IFRD1	KLHL41
Description		interferon related developmental regulator 1	kelch like family member 41
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Sarcoplasm	Ruffle Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Membrane Sarcoplasmic Reticulum Pseudopodium M Band Cul3-RING Ubiquitin Ligase Complex Sarcoplasmic Reticulum Membrane Cell Projection
	Molecular Function		Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Myoblast Fate Determination Striated Muscle Tissue Development Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Axon Extension Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration Fat Cell Differentiation Negative Regulation Of Collateral Sprouting Adipose Tissue Development	Striated Muscle Contraction Protein Ubiquitination Myofibril Assembly Skeletal Muscle Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Myoblast Differentiation Regulation Of Myoblast Proliferation Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Dental caries (decayed, missing and filled teeth) ( 31533690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mortality in heart failure ( 20400778) Osteoarthritis (hip) ( 23989986) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CSNK2A1 HDAC2 HDAC4 KLHL41 MYOD1 PDE4B RIT1	9 interacting genes: IFRD1 MYBPC1 NRAP POMP RBM4 RCHY1 SLC2A4 SPMIP2 TCAP
Entrez ID		3475	10324
HPRD ID		04612	07610
Ensembl ID		ENSG00000006652	ENSG00000239474
Uniprot IDs		A4D0U1 O00458	O60662
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By Competitive Promoter Binding Protein Lysine Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Sin3-type Complex Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cardiac Muscle Hypertrophy Muscle Hypertrophy Regulation Of Myoblast Proliferation DNA-binding Transcription Activator Activity Muscle System Process Histone Deacetylase Complex Regulation Of Cell Population Proliferation Regulation Of Myotube Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Male Mating Behavior Promoter-specific Chromatin Binding Regulation Of Myoblast Differentiation Regulation Of Striated Muscle Cell Differentiation Cellular Response To Lipid Protein De-2-hydroxyisobutyrylase Activity Myoblast Fate Determination Negative Regulation Of Relaxation Of Cardiac Muscle Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Histone Deacetylase Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Protein Decrotonylase Activity Histone Decrotonylase Activity Positive Regulation Of SnRNA Transcription By RNA Polymerase II Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Muscle Cell Differentiation Positive Regulation Of Aggrephagy Hair Follicle Placode Formation Histone Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Hydrolase Activity Protein Metabolic Process Protein Modification Process DNA-binding Transcription Factor Binding Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Dopamine	Titin Binding
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