RGL1 and RIT1

Number of citations of the paper that reports this interaction (PubMedID 10545207)
0

Data Source:
HPRD (in vitro)

		RGL1	RIT1
Description		ral guanine nucleotide dissociation stimulator like 1	Ras like without CAAX 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane	Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction	Signal Transduction Ras Protein Signal Transduction
Pathways		PPARA activates gene expression RAF/MAP kinase cascade	Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Antipsychotic drug-induced QTc interval change in schizophrenia ( 29064910) Aspartate aminotransferase levels ( 33547301 33339817 29403010) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Immature fraction of reticulocytes ( 32888494) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Response to antidepressants ( 20360315) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Retinal detachment or retinal break ( 31816047)	Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		5 interacting genes: APP FOXP1 HRAS RIT1 RIT2	16 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2
Entrez ID		23179	6016
HPRD ID		12032	10195
Ensembl ID		ENSG00000143344	ENSG00000143622
Uniprot IDs		B7Z2W5 B7Z915 B7ZB61 Q9NZL6	Q92963
PDB IDs		7SCW 7SCX	4KLZ
Enriched GO Terms of Interacting Partners?		GDP Binding G Protein Activity Ras Protein Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Regulation Of Neuronal Synaptic Plasticity Myeloid Cell Development Macrophage Activation Glial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Cell Body Positive Regulation Of MAPK Cascade Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of JNK Cascade Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Type II Interferon Production Regulation Of Calcium-mediated Signaling Positive Regulation Of Signal Transduction Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cell Motility Acetylcholine Receptor Activator Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Signal Transduction Regulation Of Cell Projection Organization Regulation Of Interleukin-1 Production Positive Regulation Of Cell Communication Regulation Of Type II Interferon Production Positive Regulation Of Signaling Lipoprotein Particle Myeloid Leukocyte Activation Positive Regulation Of Locomotion Positive Regulation Of Protein Import Regulation Of MAPK Cascade GTPase Complex Positive Regulation Of Interleukin-21 Production PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Cell Activation Involved In Immune Response Endosome To Plasma Membrane Transport Vesicle	I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Signal Transduction Wnt Signaling Pathway Paraxial Mesoderm Morphogenesis R-SMAD Binding Intracellular Signaling Cassette Mesoderm Morphogenesis Gastrulation Pericardium Development SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Tissue Development Regulation Of Neuron Projection Development Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Ras Protein Signal Transduction Positive Regulation Of Gene Expression Primary MiRNA Processing Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Neuron Projection Arborization Cell Surface Receptor Signaling Pathway Regulation Of Ossification COPII Vesicle Coating Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Localization SMAD Protein Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Developmental Growth Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cellular Developmental Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytosol Endoderm Development MiRNA Processing Vesicle Coating Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ureteric Bud Development Negative Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Cellular Component Organization Mesonephric Epithelium Development
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