RGL1

Description		ral guanine nucleotide dissociation stimulator like 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways		PPARA activates gene expression RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Antipsychotic drug-induced QTc interval change in schizophrenia ( 29064910) Aspartate aminotransferase levels ( 33547301 33339817 29403010) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Immature fraction of reticulocytes ( 32888494) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Response to antidepressants ( 20360315) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Retinal detachment or retinal break ( 31816047)
Interacting Genes		5 interacting genes: APP FOXP1 HRAS RIT1 RIT2
Entrez ID		23179
HPRD ID		12032
Ensembl ID		ENSG00000143344
Uniprot IDs		B7Z2W5 B7Z915 B7ZB61 Q9NZL6
PDB IDs		7SCW 7SCX
Enriched GO Terms of Interacting Partners?		GDP Binding G Protein Activity Ras Protein Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Regulation Of Neuronal Synaptic Plasticity Myeloid Cell Development Macrophage Activation Glial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Cell Body Positive Regulation Of MAPK Cascade Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of JNK Cascade Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Type II Interferon Production Regulation Of Calcium-mediated Signaling Positive Regulation Of Signal Transduction Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cell Motility Acetylcholine Receptor Activator Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Signal Transduction Regulation Of Cell Projection Organization Regulation Of Interleukin-1 Production Positive Regulation Of Cell Communication Regulation Of Type II Interferon Production Positive Regulation Of Signaling Lipoprotein Particle Myeloid Leukocyte Activation Positive Regulation Of Locomotion Positive Regulation Of Protein Import Regulation Of MAPK Cascade GTPase Complex Positive Regulation Of Interleukin-21 Production PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Cell Activation Involved In Immune Response Endosome To Plasma Membrane Transport Vesicle
Tagcloud ?