PFDN4 and RFPL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFDN4	RFPL3
Description		prefoldin subunit 4	ret finger protein like 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex Protein-containing Complex	Nucleus Cytoplasm
	Molecular Function	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Regulation Of Gene Expression Innate Immune Response
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Creatinine levels ( 31015462) HDL cholesterol levels in HIV infection ( 33109212) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Obesity-related traits ( 23251661)	Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196)
Interacting Genes		6 interacting genes: ACTB ERBB3 PFDN2 RFPL3 TUBA4A TUBB	11 interacting genes: C3orf62 DDIT4L EIF1AX HSPB2 HSPB2-C11orf52 LNX1 PFDN4 POF1B RGP1 SLAIN1 UBE2I
Entrez ID		5203	10738
HPRD ID		05358	09339
Ensembl ID		ENSG00000101132	ENSG00000128276
Uniprot IDs		Q9NQP4	O75679
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Norepinephrine Uptake Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Nucleotide Binding Regulation Of Transepithelial Transport Protein-containing Complex Protein Localization To Adherens Junction Dense Body Transporter Regulator Activity ErbB-3 Class Receptor Binding Neuregulin Receptor Activity Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Mitotic Cell Cycle Structural Constituent Of Postsynaptic Actin Cytoskeleton Morphogenesis Of A Polarized Epithelium Schwann Cell Differentiation Prefoldin Complex Odontoblast Differentiation BBAF Complex Tat Protein Binding Nitric-oxide Synthase Regulator Activity Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Negative Regulation Of Motor Neuron Apoptotic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway RPAP3/R2TP/prefoldin-like Complex Microtubule Cytoskeleton GTPase Activating Protein Binding Nuclear Envelope Lumen Brahma Complex Nitric-oxide Synthase Binding NBAF Complex Apical Protein Localization RSC-type Complex Adherens Junction Assembly Postsynaptic Actin Cytoskeleton Organization NpBAF Complex GBAF Complex Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activator Activity Endocardial Cushion Development Ubiquitin Protein Ligase Binding Negative Regulation Of Amyloid Fibril Formation
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