PFDN4 and PFDN2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PFDN4	PFDN2
Description		prefoldin subunit 4	prefoldin subunit 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Prefoldin Complex Protein-containing Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Protein Folding Protein Stabilization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Amyloid Fibril Formation
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Creatinine levels ( 31015462) HDL cholesterol levels in HIV infection ( 33109212) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Obesity-related traits ( 23251661)
Interacting Genes		6 interacting genes: ACTB ERBB3 PFDN2 RFPL3 TUBA4A TUBB	10 interacting genes: CEBPA DBI ERBB3 MAP3K3 PFDN1 PFDN4 PKNOX1 UBASH3A VBP1 ZNF726
Entrez ID		5203	5202
HPRD ID		05358	09658
Ensembl ID		ENSG00000101132	ENSG00000143256
Uniprot IDs		Q9NQP4	B1AQP2 Q9UHV9
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Norepinephrine Uptake Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Nucleotide Binding Regulation Of Transepithelial Transport Protein-containing Complex Protein Localization To Adherens Junction Dense Body Transporter Regulator Activity ErbB-3 Class Receptor Binding Neuregulin Receptor Activity Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Mitotic Cell Cycle Structural Constituent Of Postsynaptic Actin Cytoskeleton Morphogenesis Of A Polarized Epithelium Schwann Cell Differentiation Prefoldin Complex Odontoblast Differentiation BBAF Complex Tat Protein Binding Nitric-oxide Synthase Regulator Activity Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Negative Regulation Of Motor Neuron Apoptotic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway RPAP3/R2TP/prefoldin-like Complex Microtubule Cytoskeleton GTPase Activating Protein Binding Nuclear Envelope Lumen Brahma Complex Nitric-oxide Synthase Binding NBAF Complex Apical Protein Localization RSC-type Complex Adherens Junction Assembly Postsynaptic Actin Cytoskeleton Organization NpBAF Complex GBAF Complex Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activator Activity Endocardial Cushion Development Ubiquitin Protein Ligase Binding Negative Regulation Of Amyloid Fibril Formation	Prefoldin Complex Negative Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Amyloid-beta Binding Unfolded Protein Binding Protein-containing Complex Regulation Of Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Protein Folding Negative Regulation Of Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Protein-lipid Complex Negative Regulation Of Protein Lipidation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Protein Metabolic Process CHOP-C/EBP Complex Regulation Of Metabolic Process Neuregulin Receptor Activity Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process White Fat Cell Proliferation Benzodiazepine Receptor Binding Long-chain Fatty Acyl-CoA Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Negative Regulation Of Lipoprotein Metabolic Process ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Dorsal Root Ganglion Development
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