PFDN4 and TUBA4A

Number of citations of the paper that reports this interaction (PubMedID 14634002)
0

Data Source:
HPRD (in vitro)

		PFDN4	TUBA4A
Description		prefoldin subunit 4	tubulin alpha 4a
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex Protein-containing Complex	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases
GWAS		Atopic dermatitis ( 23042114) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Creatinine levels ( 31015462) HDL cholesterol levels in HIV infection ( 33109212) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Obesity-related traits ( 23251661)	Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)
Interacting Genes		6 interacting genes: ACTB ERBB3 PFDN2 RFPL3 TUBA4A TUBB	53 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		5203	7277
HPRD ID		05358	01851
Ensembl ID		ENSG00000101132	ENSG00000127824
Uniprot IDs		Q9NQP4	P68366
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Norepinephrine Uptake Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Nucleotide Binding Regulation Of Transepithelial Transport Protein-containing Complex Protein Localization To Adherens Junction Dense Body Transporter Regulator Activity ErbB-3 Class Receptor Binding Neuregulin Receptor Activity Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Mitotic Cell Cycle Structural Constituent Of Postsynaptic Actin Cytoskeleton Morphogenesis Of A Polarized Epithelium Schwann Cell Differentiation Prefoldin Complex Odontoblast Differentiation BBAF Complex Tat Protein Binding Nitric-oxide Synthase Regulator Activity Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Negative Regulation Of Motor Neuron Apoptotic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway RPAP3/R2TP/prefoldin-like Complex Microtubule Cytoskeleton GTPase Activating Protein Binding Nuclear Envelope Lumen Brahma Complex Nitric-oxide Synthase Binding NBAF Complex Apical Protein Localization RSC-type Complex Adherens Junction Assembly Postsynaptic Actin Cytoskeleton Organization NpBAF Complex GBAF Complex Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activator Activity Endocardial Cushion Development Ubiquitin Protein Ligase Binding Negative Regulation Of Amyloid Fibril Formation	Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly
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