PFDN4 and TUBA4A

Number of citations of the paper that reports this interaction (PMID 14634002)
12

Data Source:
HPRD (in vitro)

		PFDN4	TUBA4A
Gene Name		prefoldin subunit 4	tubulin, alpha 4a
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex	Extracellular Region Cytosol Microtubule Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Unfolded Protein Binding Chaperone Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Protein Folding Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Platelet Degranulation Protein Folding Organelle Organization Microtubule-based Process Blood Coagulation Platelet Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding	Transport of connexons to the plasma membrane Hedgehog 'off' state Platelet degranulation Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Response to elevated platelet cytosolic Ca2+ Recruitment of mitotic centrosome proteins and complexes Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Platelet activation, signaling and aggregation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs			Vincristine Podofilox Epothilone D Epothilone B Cabazitaxel
Diseases
GWAS		Atopic dermatitis ( 23042114) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: ACTB PFDN2 TUBA4A TUBB VBP1	49 interactors: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PARK2 PFDN4 PLK1 RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SYK TAOK2 TBCB TBCE TCP1 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		5203	7277
HPRD ID		05358	01851
Ensembl ID		ENSG00000101132	ENSG00000127824
Uniprot IDs		Q9NQP4	A8MUB1 P68366
PDB IDs
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Platelet Activation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Complex Assembly Blood Coagulation Hemostasis Microtubule Cytoskeleton Organization Cellular Component Assembly Cellular Protein Metabolic Process Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Body Fluid Levels Wound Healing Cellular Macromolecular Complex Assembly Leukocyte Mediated Cytotoxicity Mitotic Cell Cycle Process Cell Activation Substantia Nigra Development Response To Wounding Platelet Aggregation Cellular Response To Interleukin-4 Mitotic Cell Cycle Microtubule-based Process Response To Interleukin-4 Innate Immune Response Neural Nucleus Development Protein Metabolic Process Retina Homeostasis	Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Regulation Of Signaling Apoptotic Process Cell Migration Cell Communication Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Movement Of Cell Or Subcellular Component Response To Organic Substance Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization 'de Novo' Posttranslational Protein Folding Cellular Response To Growth Factor Stimulus 'de Novo' Protein Folding Neurotrophin TRK Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Leukocyte Migration Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Regulation Of Microtubule-based Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		12p11 13q11 16q24 1p32 20q13 3q21 bacs cdkn1b cgh chromosomes copy cyp24 fstl1 heterozygosity hyperplastic informative loh16 loh9 narrowed overcomes p13 ppp2r3 q25 q32 rip stmn1 sv40 syntenic unappreciated	34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel
Tagcloud (Difference) ?		12p11 13q11 16q24 1p32 20q13 3q21 bacs cdkn1b cgh chromosomes copy cyp24 fstl1 heterozygosity hyperplastic informative loh16 loh9 narrowed overcomes p13 ppp2r3 q25 q32 rip stmn1 sv40 syntenic unappreciated	34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel
Tagcloud (Intersection) ?