BCL2L2 and BIK

Number of citations of the paper that reports this interaction (PMID 15694340)
428

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vitro)

		BCL2L2	BIK
Gene Name		BCL2-like 2	BCL2-interacting killer (apoptosis-inducing)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Extracellular Vesicular Exosome	Endomembrane System Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH Domain Binding	Protein Binding Protein Heterodimerization Activity BH Domain Binding
	Biological Process	Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Spermatogenesis Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein Homooligomerization Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 21743057)
Protein-Protein Interactions		14 interactors: BAD BAK1 BBC3 BCL2L11 BID BIK BMF CCDC155 FATE1 HRK PMAIP1 PPP1CA TCF4 TP53	11 interactors: APP BCL2 BCL2A1 BCL2L1 BCL2L2 CRKL FATE1 MCL1 NR2F2 SOCS3 TANK
Entrez ID		599	638
HPRD ID		03569	04547
Ensembl ID		ENSG00000129473	ENSG00000100290
Uniprot IDs		Q92843	Q13323
PDB IDs		1MK3 1O0L 1ZY3 2Y6W	2IPE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Signal Transduction Regulation Of Membrane Permeability Positive Regulation Of Protein Complex Assembly Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Intracellular Transport Mitochondrial Membrane Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Complex Assembly Regulation Of Organelle Organization Apoptotic Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Mitochondrion Organization Cell Death Death Zymogen Activation Positive Regulation Of Transport Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cellular Component Organization Regulation Of Signal Transduction Mitochondrial Transport Positive Regulation Of Neuron Death Regulation Of Signaling	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Anoikis Intracellular Signal Transduction Apoptotic Signaling Pathway Response To Stress Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Signaling Negative Regulation Of Programmed Cell Death Cell Communication Apoptotic Process Reproductive Structure Development Negative Regulation Of Cell Death Reproductive System Development Intracellular Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction Cell Death Regulation Of Signal Transduction Neuron Apoptotic Process Death Negative Regulation Of Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Death Negative Regulation Of Signaling Apoptotic Mitochondrial Changes Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Reproductive Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Developmental Process Involved In Reproduction Regulation Of Apoptotic Process Sexual Reproduction Innate Immune Response Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Stimulus
Tagcloud ?		bag1 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	abt actinomycin antagonism antagonizing bak bcl bh3 carfilzomib concurrent crc cyclohexamide ectopic ectopically enabled irreversible isogenic kras mimetic noxa overcome potently sensitized sequestered shrna synergistic synergistically synergy ultimately xl
Tagcloud (Difference) ?		bag1 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	abt actinomycin antagonism antagonizing bak bcl bh3 carfilzomib concurrent crc cyclohexamide ectopic ectopically enabled irreversible isogenic kras mimetic noxa overcome potently sensitized sequestered shrna synergistic synergistically synergy ultimately xl
Tagcloud (Intersection) ?