BCL2L2 and SLC39A6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BCL2L2	SLC39A6
Description		BCL2 like 2	solute carrier family 39 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Lamellipodium Membrane Cell Projection Membrane Raft
	Molecular Function	Protein Binding Channel Activity Identical Protein Binding Disordered Domain Specific Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Metal Ion Transmembrane Transporter Activity Monoatomic Cation:bicarbonate Symporter Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Epithelial To Mesenchymal Transition Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Bicarbonate Transport Metal Ion Transport Intracellular Monoatomic Cation Homeostasis Lymphocyte Activation T Cell Receptor Signaling Pathway Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane
Pathways			Zinc influx into cells by the SLC39 gene family
Drugs		Navitoclax
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)	Esophageal squamous cell cancer (length of survival) ( 23644492)
Interacting Genes		53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CEBPA CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35E3 SLC35H1 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53	6 interacting genes: BCL2L2 MTNR1B RETREG3 SLC10A6 SPP1 TMEM31
Entrez ID		599	25800
HPRD ID		03569	12285
Ensembl ID		ENSG00000129473	ENSG00000141424
Uniprot IDs		Q92843	Q13433
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Apoptotic Mitochondrial Changes Apoptotic Process Positive Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Positive Regulation Of Programmed Cell Death Programmed Cell Death Mitochondrial Outer Membrane Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrion Organization Cellular Response To Stress Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein-containing Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Fibroblast Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Organelle Organization Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Hypoxia Lymphocyte Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Decreased Oxygen Levels Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Triglyceride Metabolic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxygen Levels Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Identical Protein Binding Leukocyte Apoptotic Process Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Sertoli Cell Proliferation Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Androgen Catabolic Process Cellular Response To Testosterone Stimulus Endoplasmic Reticulum-autophagosome Adaptor Activity Bile Acid:sodium Symporter Activity Response To 2,3,7,8-tetrachlorodibenzodioxine Substrate Localization To Autophagosome Bcl-2 Family Protein Complex Response To Macrophage Colony-stimulating Factor Regulation Of Hormone Secretion Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Positive Regulation Of Bone Resorption Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration
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