BCL2L2 and BBC3

Number of citations of the paper that reports this interaction (PubMedID 16697956)
0

Data Source:
HPRD (in vitro)

		BCL2L2	BBC3
Description		BCL2 like 2	BCL2 binding component 3
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Mitochondrion Mitochondrial Outer Membrane Lysosome Cytosol
	Molecular Function	Protein Binding Channel Activity Identical Protein Binding Disordered Domain Specific Binding	Protein Binding ATPase Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Determination Of Adult Lifespan Positive Regulation Of Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs		Navitoclax
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Monocyte count ( 27863252) White blood cell count ( 32888494)
Interacting Genes		53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CEBPA CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35E3 SLC35H1 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53	15 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FBXL20 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438
Entrez ID		599	27113
HPRD ID		03569	16165
Ensembl ID		ENSG00000129473	ENSG00000105327
Uniprot IDs		Q92843	Q96PG8 Q9BXH1
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM	2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP 7DVD 7P0S 7P9W 7QTX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Apoptotic Mitochondrial Changes Apoptotic Process Positive Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Positive Regulation Of Programmed Cell Death Programmed Cell Death Mitochondrial Outer Membrane Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrion Organization Cellular Response To Stress Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein-containing Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Fibroblast Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Organelle Organization Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Hypoxia Lymphocyte Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Decreased Oxygen Levels Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Triglyceride Metabolic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxygen Levels Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Identical Protein Binding Leukocyte Apoptotic Process Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death	Release Of Cytochrome C From Mitochondria Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity BH3 Domain Binding Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Mitochondrion Organization Apoptotic Signaling Pathway Mitochondrial Membrane Mitochondrial Fusion Negative Regulation Of Anoikis Programmed Cell Death Involved In Cell Development Regulation Of Anoikis Regulation Of Nitrogen Utilization Retinal Cell Programmed Cell Death Dendritic Cell Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Ovarian Follicle Development Leukocyte Apoptotic Process Sertoli Cell Proliferation Response To Gamma Radiation Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Developmental Pigmentation Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential DNA Damage Response Negative Regulation Of Apoptotic Signaling Pathway B Cell Apoptotic Process Calcium Ion Transport Into Cytosol Negative Regulation Of Apoptotic Process Regulation Of Developmental Pigmentation Pore Complex Regulation Of Neuron Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Motor Neuron Apoptotic Process Regulation Of Motor Neuron Apoptotic Process Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Death
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