BCL2L2 and LRRIQ1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BCL2L2	LRRIQ1
Description		BCL2 like 2	leucine rich repeats and IQ motif containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Microtubule Cytoskeleton
	Molecular Function	Protein Binding Channel Activity Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Apoptotic Process Single Fertilization Regulation Of Signal Transduction Gene Expression Ectopic Germ Cell Programmed Cell Death
Pathways
Drugs		Navitoclax
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)	Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Monobrow ( 27182965) Optic disc size ( 31809533)
Interacting Genes		53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CEBPA CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35E3 SLC35H1 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53	2 interacting genes: BCL2L2 EMILIN1
Entrez ID		599	84125
HPRD ID		03569	09952
Ensembl ID		ENSG00000129473	ENSG00000133640
Uniprot IDs		Q92843	A0A140VJN5 Q96JM4
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Apoptotic Mitochondrial Changes Apoptotic Process Positive Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Positive Regulation Of Programmed Cell Death Programmed Cell Death Mitochondrial Outer Membrane Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrion Organization Cellular Response To Stress Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein-containing Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Fibroblast Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Organelle Organization Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Hypoxia Lymphocyte Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Decreased Oxygen Levels Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Triglyceride Metabolic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxygen Levels Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Identical Protein Binding Leukocyte Apoptotic Process Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death	Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Sertoli Cell Proliferation Bcl-2 Family Protein Complex Integrin Binding Involved In Cell-matrix Adhesion Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway EMILIN Complex Positive Regulation Of Defense Response To Bacterium Regulation Of Collagen Fibril Organization Integrin Alpha4-beta1 Complex Positive Regulation Of Platelet Aggregation Positive Regulation Of Extracellular Matrix Assembly Extracellular Matrix Constituent Conferring Elasticity Elastic Fiber Assembly Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Collagen Biosynthetic Process Regulation Of Defense Response To Bacterium Negative Regulation Of Macrophage Migration Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Release Of Cytochrome C From Mitochondria Disordered Domain Specific Binding Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Coagulation Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Regulation Of Platelet Aggregation Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Blood Coagulation Cell Adhesion Mediated By Integrin Extracellular Matrix Assembly Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Aortic Valve Morphogenesis Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Mononuclear Cell Migration Regulation Of Collagen Biosynthetic Process Channel Activity Regulation Of Collagen Metabolic Process Regulation Of Macrophage Migration Negative Regulation Of Leukocyte Migration Regulation Of Platelet Activation Heart Valve Morphogenesis Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Positive Regulation Of Wound Healing Negative Regulation Of ERK1 And ERK2 Cascade
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