NRTN and NFIX

		NRTN	NFIX
Description		neurturin	nuclear factor I X
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus
	Molecular Function	Signaling Receptor Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding Heparan Sulfate Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Neural Crest Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Nerve Development Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) N-glycan levels ( 21203500 21908519 31163085)	Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area ( 32963231) Cortical volume ( 32963231) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: GFRA1 GFRA2 RET	24 interacting genes: JMJD6 LHX4 NFIB PAX2 PAX6 PAX7 PAX8 PIR PRDM1 QRICH1 RFX1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614
Entrez ID		4902	4784
HPRD ID		03604	01234
Ensembl ID		ENSG00000171119	ENSG00000008441
Uniprot IDs		Q99748	B4DHW2 D2DXM9 Q14938
PDB IDs		5MR4 5MR5 5MR9 5NMZ 6GL7 6Q2O 6Q2R	7QQD 7QQE
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Activity Receptor Complex Extrinsic Component Of Membrane Plasma Membrane Protein Complex Signaling Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Side Of Membrane Posterior Midgut Development Kidney Development Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development System Development Neurotrophin Receptor Activity Ureter Maturation GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development Heparan Sulfate Binding Lymphocyte Migration Into Lymphoid Organs External Side Of Plasma Membrane Positive Regulation Of Kidney Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Differentiation Positive Regulation Of Cell Size Enteric Nervous System Development Axon Neuron Cell-cell Adhesion Response To Pain Neuron Projection Development Positive Regulation Of Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Embryonic Epithelial Tube Formation Neurotrophin Signaling Pathway Neuron Maturation Epithelial Tube Formation Membrane Protein Proteolysis Regulation Of Kidney Development Metanephros Development	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization
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