AFAP1L2

Description		actin filament associated protein 1 like 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding
	Biological Process	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Systolic blood pressure ( 29212154)
Interacting Genes		10 interacting genes: ACD APP ATXN1L POT1 RASA1 SH3PXD2A SRC TERF1 TERF2 TINF2
Entrez ID		84632
HPRD ID		13902
Ensembl ID		ENSG00000169129
Uniprot IDs		A0A8Q3SIY9 B7Z2Q0 Q8N4X5
PDB IDs		2COF
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Telomere Assembly RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Telomere Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization DNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Telomerase Positive Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Cellular Component Organization Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Chromosome Organization Negative Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Protection From Non-homologous End Joining At Telomere Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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