AFAP1L2

Gene Name		actin filament associated protein 1-like 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane
	Molecular Function	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-protein Interactions		9 interactors: ACD APP ATXN1L POT1 RASA1 SRC TERF1 TERF2 TINF2
Entrez ID		84632
HPRD ID		13902
Ensembl ID		ENSG00000169129
Uniprot IDs		F5GZE1 Q8N4X5
PDB IDs		2COF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Assembly Telomere Capping Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Protein Localization To Chromosome, Telomeric Region Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Localization To Chromosome Positive Regulation Of Organelle Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Regulation Of Cellular Component Organization Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Telomerase Activity Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Chromosome Organization Cellular Component Assembly DNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Positive Regulation Of Catalytic Activity DNA Replication
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