CSAD and RAP1B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CSAD	RAP1B
Gene Name		cysteine sulfinic acid decarboxylase	RAP1B, member of RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component		Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Sulfinoalanine Decarboxylase Activity Pyridoxal Phosphate Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Sulfur Amino Acid Catabolic Process Cellular Nitrogen Compound Metabolic Process Taurine Biosynthetic Process Small Molecule Metabolic Process	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Degradation of cysteine and homocysteine Sulfur amino acid metabolism Metabolism of amino acids and derivatives	Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs		Pyridoxal Phosphate L-Cysteine
Diseases
GWAS		Obesity-related traits ( 23251661)	White blood cell count ( 20139978)
Protein-Protein Interactions		10 interactors: ANXA1 ANXA7 CDKN1A GSK3B NR1H2 PIN1 RAP1B RCC1 SMN1 TK1	29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		51380	5908
HPRD ID		16763	01546
Ensembl ID		ENSG00000139631	ENSG00000127314
Uniprot IDs		Q86V02 Q96JQ3 Q9Y600	B7ZAY2 P61224
PDB IDs		2JIS	3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Response To Organic Cyclic Compound Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Negative Regulation Of Transport Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Ras GTPase Activity Response To Inorganic Substance Response To Steroid Hormone Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Response To Glucocorticoid Regulation Of Cell Cycle Process Cellular Response To Organic Substance Response To Corticosteroid Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Ras GTPase Activity Epithelial Cell Differentiation Response To X-ray Positive Regulation Of Protein Metabolic Process Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Protein Transport Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Ras Protein Signal Transduction Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Phosphorylation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Regulation Of Protein Localization Positive Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Phosphorylation Response To Metal Ion Cellular Response To Heat Positive Regulation Of Protein Modification Process Tissue Development Regulation Of Organelle Organization Regulation Of Vesicle-mediated Transport Regulation Of Cell Cycle Response To Hormone Positive Regulation Of High-density Lipoprotein Particle Assembly Neutrophil Clearance Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion	Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization
Tagcloud ?		ado birth blotting born cdo deficiency died disruption drinking engineered g2 g3 gpx hplc indicated ko lactoferrin northern offspring physiological prolactin restored southern studying supplementation survived taurine taut verified	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Difference) ?		ado birth blotting born cdo deficiency died disruption drinking engineered g2 g3 gpx hplc indicated ko lactoferrin northern offspring physiological prolactin restored southern studying supplementation survived taurine taut verified	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
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