CSAD and SH2B1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		CSAD	SH2B1
Description		cysteine sulfinic acid decarboxylase	SH2B adaptor protein 1
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GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Aspartate 1-decarboxylase Activity Sulfinoalanine Decarboxylase Activity Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity
	Biological Process	L-cysteine Catabolic Process To Hypotaurine L-cysteine Catabolic Process To Taurine Carboxylic Acid Metabolic Process Taurine Biosynthetic Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Cell Motility Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process
Pathways		Degradation of cysteine and homocysteine	Factors involved in megakaryocyte development and platelet production
Drugs		Pyridoxal phosphate Cysteine
Diseases
GWAS		Fulminant type 1 diabetes ( 30552108) Obesity-related traits ( 23251661)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 19079260 29381148 28448500 19079261 20935630) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		11 interacting genes: ANXA1 ANXA7 CDKN1A GSK3B NR1H2 PIN1 RAP1B RCC1 SH2B1 SMN1 TK1	19 interacting genes: CRK CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 HUNK IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2
Entrez ID		51380	25970
HPRD ID		16763	12336
Ensembl ID		ENSG00000139631	ENSG00000178188
Uniprot IDs		Q86V02 Q96JQ3 Q9Y600	B3KNV5 B4DLN5 Q9NRF2
PDB IDs		2JIS	5W3R
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cytoplasm Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Exocytosis Vesicle Membrane Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Nucleus Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Tau Protein Binding Calcium-dependent Phospholipid Binding Regulation Of Organelle Organization Phosphatidylserine Binding Small GTPase-mediated Signal Transduction Regulation Of Microtubule Anchoring At Centrosome Cis-trans Isomerase Activity Positive Regulation Of Secretion Of Lysosomal Enzymes Cellular Developmental Process Keratinocyte Differentiation Cytosol Regulation Of SMAD Protein Signal Transduction Calcium-dependent Protein Binding PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Thymidine Kinase Activity Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Regulation Of DNA Biosynthetic Process Epithelial Cell Differentiation Cell Differentiation Epidermal Cell Differentiation Positive Regulation Of Protein Modification Process Intracellular Signaling Cassette Cellular Component Assembly Beta-catenin Binding Protein Peptidyl-prolyl Isomerization	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Kinase Activity Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Substrate Binding Peptidyl-tyrosine Phosphorylation ATP Binding Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB2 Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Plasma Membrane ERBB Signaling Pathway Nucleotide Binding Transferase Activity Response To Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Neuron Differentiation Signal Transduction Phosphorylation Regulation Of Signal Transduction Cell Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Identical Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Endosome Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase Binding Cellular Developmental Process Positive Regulation Of Phosphate Metabolic Process Schwann Cell Development ERBB3:ERBB2 Complex Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation
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