RIT2

Gene Name		Ras-like without CAAX 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane
	Molecular Function	GTPase Activity Calmodulin Binding GTP Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Neurotrophin TRK Receptor Signaling Pathway
Pathways		Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Cognitive performance ( 19734545) Parkinson's disease ( 22451204 21738487)
Protein-protein Interactions		12 interactors: APP CALM1 HRAS MLLT4 PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2
Entrez ID		6014
HPRD ID		15253
Ensembl ID		ENSG00000152214
Uniprot IDs		Q99578
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of GTPase Activity Blood Coagulation Signaling Hemostasis Cell Communication Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Cell Development Neuron Projection Morphogenesis Intracellular Signal Transduction Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Cell Projection Assembly Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Ras GTPase Activity Cell Differentiation Cell-cell Signaling Suckling Behavior Neuron Development Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Anatomical Structure Development Cellular Response To Fibroblast Growth Factor Stimulus Cell Morphogenesis Regulation Of Ras GTPase Activity
Tagcloud ?		advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted