RIT2 and RGL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIT2	RGL3
Description		Ras like without CAAX 2	ral guanine nucleotide dissociation stimulator like 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Chromatin Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding Semaphorin Receptor Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways		Signalling to p38 via RIT and RIN	RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30679032) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 28892062 26426971) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 21738487 22451204 32310270 32201043 25064009 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)	Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618447 27618448 27841878) Hypertension ( 27618447 27618448 32709000 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 27618447) Systolic blood pressure ( 28135244 27841878 30578418 27618448 27618447)
Interacting Genes		13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2	6 interacting genes: FAM200A KLHL12 NRAS RIT1 RIT2 RRAS2
Entrez ID		6014	57139
HPRD ID		15253	18844
Ensembl ID		ENSG00000152214	ENSG00000205517
Uniprot IDs		Q99578	Q3MIN7
PDB IDs
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Signal Transduction GTPase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Small GTPase-mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Glial Cell Development Positive Regulation Of Neuron Apoptotic Process Guanyl-nucleotide Exchange Factor Activity Regulation Of Neuron Apoptotic Process Schwann Cell Development Positive Regulation Of Gene Expression Plasma Membrane Endocytosis Cell Development Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Projection Assembly Proprioception Involved In Equilibrioception Synapse Organization Import Into Cell Cell Junction Assembly Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Projection Organization Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Chemotaxis Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Type II Interferon Production Cell Surface Receptor Signaling Pathway Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import	Ras Protein Signal Transduction GDP Binding Small GTPase-mediated Signal Transduction G Protein Activity GTPase Activity GTP Binding Intracellular Signaling Cassette Hydrolase Activity Dendritic Tree Positive Regulation Of Schwann Cell Migration Schwann Cell Migration Nucleotide Binding Intracellular Signal Transduction Calmodulin Binding MAPK Cascade Neural Crest Formation Positive Regulation Of Glial Cell Migration Regulation Of Cdc42 Protein Signal Transduction Signal Transduction
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