RIT2 and PLXNB3

Number of citations of the paper that reports this interaction (PubMedID 16122393)
56

Data Source:
HPRD (two hybrid, in vivo)

		RIT2	PLXNB3
Description		Ras like without CAAX 2	plexin B3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane
	Molecular Function	Nucleotide Binding Chromatin Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding Semaphorin Receptor Binding Identical Protein Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Synapse Assembly Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways		Signalling to p38 via RIT and RIN	Other semaphorin interactions
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30679032) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 28892062 26426971) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 21738487 22451204 32310270 32201043 25064009 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2	10 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 DSCR9 HSPA13 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		6014	5365
HPRD ID		15253	02198
Ensembl ID		ENSG00000152214	ENSG00000198753
Uniprot IDs		Q99578	A8K920 Q9ULL4
PDB IDs
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Signal Transduction GTPase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Small GTPase-mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Glial Cell Development Positive Regulation Of Neuron Apoptotic Process Guanyl-nucleotide Exchange Factor Activity Regulation Of Neuron Apoptotic Process Schwann Cell Development Positive Regulation Of Gene Expression Plasma Membrane Endocytosis Cell Development Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Projection Assembly Proprioception Involved In Equilibrioception Synapse Organization Import Into Cell Cell Junction Assembly Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Projection Organization Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Chemotaxis Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Type II Interferon Production Cell Surface Receptor Signaling Pathway Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import	Cullin-RING Ubiquitin Ligase Complex
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