RAC3 and ARFIP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAC3	ARFIP2
Description		Rac family small GTPase 3	ARF interacting protein 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Lamellipodium Growth Cone Cytoplasmic Vesicle Filamentous Actin Cell Projection Neuron Projection NADPH Oxidase Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse	Ruffle Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Trans-Golgi Network Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding Calcium-dependent Protein Binding	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase-mediated Signal Transduction Motor Neuron Axon Guidance Regulation Of Cell Shape Regulation Of Cell-substrate Adhesion Regulation Of Neuron Maturation Wnt Signaling Pathway Rac Protein Signal Transduction Cerebral Cortex GABAergic Interneuron Development Regulation Of Cell Morphogenesis Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Respiratory Burst Homeostasis Of Number Of Cells Within A Tissue Neuromuscular Process Controlling Balance Neuromuscular Process Synaptic Transmission, GABAergic Cell Chemotaxis Postsynaptic Actin Cytoskeleton Organization Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Migration	Mitophagy Intracellular Protein Transport Autophagy Small GTPase-mediated Signal Transduction Intracellular Protein Localization Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Phagophore Assembly Site
Pathways		PCP/CE pathway RAC3 GTPase cycle	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Malaria ( 31844061)
Interacting Genes		9 interacting genes: ANKRD11 AR ARFIP2 ARHGDIB CIB1 ESR1 HDAC7 HNF1A NRBP1	61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1
Entrez ID		5881	23647
HPRD ID		03629	07209
Ensembl ID		ENSG00000169750	ENSG00000132254
Uniprot IDs		P60763	A0A087X1E4 B4DUZ3 B4DXH2 P53365
PDB IDs		2C2H 2G0N 2IC5 2OV2 2QME 6TM1	1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?		Regulation Of Reproductive Process Estrogen Response Element Binding Prostate Gland Growth Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Steroid Binding 14-3-3 Protein Binding Prostate Induction Organ Growth Transcription Coactivator Binding Nuclear Receptor Activity Response To Estrogen Male Somatic Sex Determination Regulation Of Morphogenesis Of A Branching Structure Small GTPase Binding Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Morphogenesis Of An Epithelium Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Reproductive Process Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis ATPase Binding Regulation Of MiRNA Metabolic Process Regulation Of Pronephros Size Beta-catenin Binding Regulation Of Protein Localization To Plasma Membrane Chromatin Binding Male Genitalia Morphogenesis Cytoplasm POU Domain Binding Male Gonad Development Nuclear Receptor-mediated Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Integrin Biosynthetic Process Rho GDP-dissociation Inhibitor Activity Cellular Response To Redox State Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of DNA-binding Transcription Factor Activity	Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Transport Regulation Of Endocytosis GTPase Activity Cellular Localization Protein Binding Protein Transport Regulation Of Receptor-mediated Endocytosis GTP Binding Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization Organelle Organization Regulation Of Postsynapse Organization Cerebral Cortex GABAergic Interneuron Development Intracellular Transport Regulation Of Organelle Organization Regulation Of Cellular Localization Membrane Organization Positive Regulation Of Establishment Of Protein Localization Intracellular Protein Transport Cortical Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Intracellular Protein Localization PTB Domain Binding Regulation Of Dendritic Spine Development Respiratory Burst Lamellipodium Golgi Vesicle Transport Establishment Of Localization In Cell Positive Regulation Of Secretion By Cell Regulation Of Synapse Organization Negative Regulation Of Endocytosis Regulation Of Establishment Of Protein Localization Regulation Of Cytoskeleton Organization Synaptic Vesicle Membrane Erythrocyte Enucleation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Secretion Regulation Of Receptor Internalization Postsynapse Cytoskeleton Organization Negative Regulation Of Receptor-mediated Endocytosis Endocytosis Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Mitotic Cytokinetic Process
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