RAC3 and HDAC7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAC3	HDAC7
Description		Rac family small GTPase 3	histone deacetylase 7
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Lamellipodium Growth Cone Cytoplasmic Vesicle Filamentous Actin Cell Projection Neuron Projection NADPH Oxidase Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding Calcium-dependent Protein Binding	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity SUMO Transferase Activity Protein Kinase Binding Protein Lysine Deacetylase Activity Metal Ion Binding 14-3-3 Protein Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase-mediated Signal Transduction Motor Neuron Axon Guidance Regulation Of Cell Shape Regulation Of Cell-substrate Adhesion Regulation Of Neuron Maturation Wnt Signaling Pathway Rac Protein Signal Transduction Cerebral Cortex GABAergic Interneuron Development Regulation Of Cell Morphogenesis Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Respiratory Burst Homeostasis Of Number Of Cells Within A Tissue Neuromuscular Process Controlling Balance Neuromuscular Process Synaptic Transmission, GABAergic Cell Chemotaxis Postsynaptic Actin Cytoskeleton Organization Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Migration	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Chromatin Organization Protein Deacetylation Cell-cell Junction Assembly Negative Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Negative Regulation Of Interleukin-2 Production Epigenetic Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of MRNA Processing Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Membraneless Organelle Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		PCP/CE pathway RAC3 GTPase cycle	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Valproic acid Decitabine Vorinostat Trichostatin A Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Refractive error ( 32231278)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Fasting insulin ( 34059833) Haemorrhoidal disease ( 33888516) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: ANKRD11 AR ARFIP2 ARHGDIB CIB1 ESR1 HDAC7 HNF1A NRBP1	59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRABD2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 MTCL2 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 UBC UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16
Entrez ID		5881	51564
HPRD ID		03629	09133
Ensembl ID		ENSG00000169750	ENSG00000061273
Uniprot IDs		P60763	Q8WUI4
PDB IDs		2C2H 2G0N 2IC5 2OV2 2QME 6TM1	3C0Y 3C0Z 3C10 3ZNR 3ZNS 8Q9Q
Enriched GO Terms of Interacting Partners?		Regulation Of Reproductive Process Estrogen Response Element Binding Prostate Gland Growth Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Steroid Binding 14-3-3 Protein Binding Prostate Induction Organ Growth Transcription Coactivator Binding Nuclear Receptor Activity Response To Estrogen Male Somatic Sex Determination Regulation Of Morphogenesis Of A Branching Structure Small GTPase Binding Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Morphogenesis Of An Epithelium Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Reproductive Process Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis ATPase Binding Regulation Of MiRNA Metabolic Process Regulation Of Pronephros Size Beta-catenin Binding Regulation Of Protein Localization To Plasma Membrane Chromatin Binding Male Genitalia Morphogenesis Cytoplasm POU Domain Binding Male Gonad Development Nuclear Receptor-mediated Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Integrin Biosynthetic Process Rho GDP-dissociation Inhibitor Activity Cellular Response To Redox State Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of DNA-binding Transcription Factor Activity	Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Protein Lysine Deacetylase Activity Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Chromatin Binding Histone Deacetylase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Protein Lysine Delactylase Activity Negative Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Cell Motility Regulation Of Striated Muscle Cell Differentiation Transcription Corepressor Binding Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Migration Regulation Of Cell Differentiation Regulation Of Gene Expression Neuron Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding NF-kappaB Binding Signal Transduction
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