SERPINA4 and ILK

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SERPINA4	ILK
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	integrin-linked kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Stress Fiber Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Cell Junction Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft Protein Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Protein Serine/threonine Kinase Activity Signal Transducer Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity	Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Extracellular Fibril Organization Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Protein Heterooligomerization Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			Cell junction organization Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Vaspin levels ( 22907691)
Protein-Protein Interactions		13 interactors: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1D1	35 interactors: AKT1 CASP8 CASP9 CAV1 CKB GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		5267	3611
HPRD ID		01004	03842
Ensembl ID		ENSG00000100665	ENSG00000166333
Uniprot IDs		P29622	B7Z1I0 B7Z418 Q13418
PDB IDs			2KBX 3F6Q 3IXE 3KMU 3KMW 3REP
Enriched GO Terms of Interacting Partners?		Activation Of MAPKKK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Activation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cellular Metabolic Process JNK Cascade Extracellular Matrix Disassembly Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Regulation Of Cell-matrix Adhesion Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Locomotion Positive Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of JNK Cascade Regulation Of Cell Adhesion Defense Response	Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Junction Assembly Cell-substrate Adhesion Response To Growth Factor Positive Regulation Of Signal Transduction Cell-matrix Adhesion Cytoskeleton Organization Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Immune System Process Actin Filament-based Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Heterotypic Cell-cell Adhesion Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Reorganization Single Organismal Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Epithelial Cell Proliferation Cell Migration Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Morphogenesis Angiogenesis Response To Fibroblast Growth Factor Cell Motility Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		academic bcl2 beadchip caucasian cohorts complicates diego discovery entirely genotyped genotyping hundred illumina injury kallistatin kidney nucleotide polymorphisms predicts rs12457893 rs8094315 san septic shock sixty split tertiary thousand validation	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Difference) ?		academic bcl2 beadchip caucasian cohorts complicates diego discovery entirely genotyped genotyping hundred illumina injury kallistatin kidney nucleotide polymorphisms predicts rs12457893 rs8094315 san septic shock sixty split tertiary thousand validation	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Intersection) ?