SERPINA4 and KLK2

Number of citations of the paper that reports this interaction (PubMedID 10991942)
0

Data Source:
HPRD (in vitro)

		SERPINA4	KLK2
Description		serpin family A member 4	kallikrein related peptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Secretory Granule Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process		Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation
Pathways		Platelet degranulation Developmental Lineage of Pancreatic Acinar Cells	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Zinc Copper Zinc acetate
Diseases
GWAS		Blood protein levels ( 30072576) Vaspin levels ( 22907691)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		14 interacting genes: CFTR CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		5267	3817
HPRD ID		01004	01006
Ensembl ID		ENSG00000100665	ENSG00000167751
Uniprot IDs		A0A024R6I9 P29622	A0A024R4J4 B4DU77 P20151
PDB IDs		6F02	4NFE 4NFF
Enriched GO Terms of Interacting Partners?			Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Extracellular Space Extracellular Exosome Extracellular Region Platelet Alpha Granule Lumen Extracellular Matrix Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Blood Microparticle Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Endopeptidase Inhibitor Activity Negative Regulation Of Plasminogen Activation Regulation Of Proteolysis Signaling Receptor Binding Positive Regulation Of Endopeptidase Activity Antibacterial Humoral Response Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Coagulation Platelet Alpha Granule Fibrinolysis Sperm Capacitation Defense Response To Bacterium Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Maturation Molecular Function Activator Activity Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Positive Regulation Of Chemotaxis Positive Regulation Of Coagulation Cell Maturation Regulation Of G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Heparin Binding Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Bacterium Epithelial Cell Morphogenesis Positive Regulation Of Supramolecular Fiber Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?