RABEP1 and ATXN7

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		RABEP1	ATXN7
Gene Name		rabaptin, RAB GTPase binding effector protein 1	ataxin 7
Image
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Endocytic Vesicle Intracellular Membrane-bounded Organelle Recycling Endosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Chromatin Binding Protein Binding
	Biological Process	Endocytosis Apoptotic Process Protein Transport Positive Regulation Of GTPase Activity Membrane Fusion	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: AP1G1 AP1G2 ATXN7 CASP3 CCND1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 ITSN2 RAB1A RAB33B RAB4A RAB5A RABGEF1 RGS17 TRIM26 TSC2 UBC YWHAG	59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
Entrez ID		9135	6314
HPRD ID		04684	06365
Ensembl ID		ENSG00000029725	ENSG00000163635
Uniprot IDs		F5H355 Q15276	O15265 Q9UPD8
PDB IDs		1P4U 1TU3 1X79	2KKR
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Intracellular Transport Establishment Of Localization In Cell Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Protein Localization Transport Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport Membrane Organization Positive Regulation Of Metabolic Process Regulation Of Exocytosis Regulation Of Phosphorylation Intracellular Signal Transduction Endocytosis Regulation Of Endocytosis Negative Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity Signal Transduction Negative Regulation Of Protein Phosphorylation Regulation Of Signaling Regulation Of Cellular Component Organization Small GTPase Mediated Signal Transduction Virion Assembly Positive Regulation Of Hydrolase Activity Apoptotic Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Cytoplasmic Transport Signaling Regulation Of Metabolic Process Positive Regulation Of GTPase Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Exocytosis Protein Targeting	Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process
Tagcloud ?		adpkd arl3 autosomal cilia ciliary ciliopathies cleaved couples gga1 golgi gps localize milieu module must pc1 pc2 polycystic polycystin proper proteolytically reach sense tgn traffic trafficking transmembrane tubular whereby	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Difference) ?		adpkd arl3 autosomal cilia ciliary ciliopathies cleaved couples gga1 golgi gps localize milieu module must pc1 pc2 polycystic polycystin proper proteolytically reach sense tgn traffic trafficking transmembrane tubular whereby	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Intersection) ?