CACTIN and CLK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CACTIN	CLK2
Description		cactin, spliceosome C complex subunit	CDC like kinase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nuclear Body Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Phosphorylation Immune System Process MRNA Processing RNA Splicing Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Protein Phosphorylation Response To Ionizing Radiation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways		mRNA Splicing - Major Pathway
Drugs			Fostamatinib
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: CLK2 HMGB2 NELFE RNF10 TRIM39	62 interacting genes: AKT1 AP2M1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUC7L LUZP4 MRPL2 MRPL4 NIP7 NXF1 PATL1 PRM1 PRPF38A PRPF6 PTPN1 RBM39 RBM6 RNF8 RNPS1 RSRP1 SDCBP SNRNP27 SRPK2 SRRM1 SRSF1 SRSF10 SRSF8 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YTHDF1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21
Entrez ID		58509	1196
HPRD ID		18930	04289
Ensembl ID		ENSG00000105298	ENSG00000176444
Uniprot IDs		Q8WUQ7	A8K7I0 B1AVT0 B7Z8N6 P49760
PDB IDs		6QDV 7W5A 7W5B 8C6J 9FMD	3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?			MRNA Metabolic Process MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing, Via Transesterification Reactions RS Domain Binding RNA Processing Nucleus RNA Metabolic Process Nuclear Speck Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of RNA Metabolic Process Zinc Ion Binding Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Metabolic Process Spliceosomal Complex Assembly Mammalian Oogenesis Stage Protein Binding MRNA Alternative Polyadenylation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein K6-linked Ubiquitination Protein Serine/threonine/tyrosine Kinase Activity Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA 3'-end Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Translational Initiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response N6-methyladenosine-containing RNA Reader Activity
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