CACTIN and NELFE

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
BioGRID (two hybrid)

		CACTIN	NELFE
Gene Name		cactin, spliceosome C complex subunit	negative elongation factor complex member E
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Mitochondrion NELF Complex
	Molecular Function	Protein Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Phosphorylation Multicellular Organismal Development Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Biological_process Gene Expression Viral Process Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways			Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: NELFE	10 interactors: CACTIN CCDC57 MTUS2 NCOR1 NELFB SRPK1 SRPK2 SUMO1 TRIM27 VAMP3
Entrez ID		58509	7936
HPRD ID		18930	01096
Ensembl ID		ENSG00000105298	ENSG00000204356
Uniprot IDs		Q8WUQ7	P18615
PDB IDs			1X5P 2BZ2 2JX2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Regulation Of DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Regulation Of Viral Process	Regulation Of Viral Process Positive Regulation Of Viral Process Negative Regulation Of Viral Process Innate Immune Response Nucleus Organization Immune System Process Positive Regulation Of Viral Genome Replication Immune Response Defense Response Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity RNA Metabolic Process RNA Splicing Gene Expression Retrograde Transport, Endosome To Golgi Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated MRNA Processing Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear Speck Organization Regulation Of MRNA Processing Regulation Of Tumor Necrosis Factor Production Regulation Of Cytokine-mediated Signaling Pathway Regulation Of RNA Splicing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process MRNA Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity RNA Processing Negative Regulation Of Immune Response
Tagcloud ?		adoption alters asymmetry cacn construct daughter elegans excessive fate l4 larval lef lit mirror modulates nlk pop poptop proper proxy respects rnai seam surprisingly sys tcf tightly uterine wnt	15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers spen taf1b tceb3c truncating wisp3 znf311
Tagcloud (Difference) ?		adoption alters asymmetry cacn construct daughter elegans excessive fate l4 larval lef lit mirror modulates nlk pop poptop proper proxy respects rnai seam surprisingly sys tcf tightly uterine wnt	15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers spen taf1b tceb3c truncating wisp3 znf311
Tagcloud (Intersection) ?